IL- 22 在结缔组织病中的作用研究进展

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摘要 Th17 和Th22 细胞是两个新兴的Th 细胞亚群，Th22 细胞主要分泌白细胞介素-22（IL-22）、白细胞介素-13（IL-13）等细胞因子和肿瘤坏死因子-α（TNF-α），其中最重要的是IL-22。IL-22 是白细胞介素-10（IL-10）细胞因子家族成员，在自身免疫性疾病、肿瘤、感染等发生发展过程中都发挥着不同程度的作用。结缔组织病是一组累及骨、关节、肌肉、血管、韧带等结缔组织的自身免疫性疾病，目前病因尚不明确。IL-22 作为一种新型的细胞因子，在结缔组织病发病中的作用备受关注，如干燥综合征、类风湿关节炎、系统性红斑狼疮、强直性脊柱炎等。文章就IL-22 在常见的结缔组织病中的研究现状做一综述。

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	吴圣霞
	邹霓

关键词 ：白细胞介素-22, Th22 细胞, 结缔组织病, 细胞因子

Abstract：Th17 and Th22 cells are two new subsets of Th cells, Th22 cells mainly secrete cytokines such as interleukin-22 (IL-22), interleukin-13 (IL-13) and tumor necrosis factor-α (TNF-α), the most important of these is IL-22.IL-22 is a member of the interleukin-10 (IL-10) cytokine family, it plays different roles in the occurrence and development of autoimmune diseases, tumors, infections and so on. Connective tissue disease is a group of autoimmune diseases involving bone, joint, muscle, blood vessel, ligament and other connective tissues. The etiology of CTD is still unclear. As a new cytokine, IL-22 has attracted much attention in the pathogenesis of connective tissue diseases, such as Sjogren′s syndrome, rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis. This article reviews the research status of IL-22 in common connective tissue diseases.

Key words： Interleukin-22 Th22 cells Connective tissue disease Cytokine

通讯作者: 邹霓（1966-），女，风湿免疫科科主任，主任医师，硕士生导师，主要从事风湿病学研究

作者简介: 吴圣霞（1992-），女，2016 级在读硕士研究生，主要从事风湿免疫学研究

引用本文:

吴圣霞；邹霓. IL- 22 在结缔组织病中的作用研究进展[J]. 中国当代医药, 2019, 26(9): 30-33.
WU Sheng-xia；ZOU Ni. Research progress on the role of IL-22 in connective tissue diseases. 中国当代医药, 2019, 26(9): 30-33.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I9/30

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