Abstract：Objective To evaluate the efficacy of Glucocorticoid combined with Cyclophosphamide in the treatment of myasthenia gravis.Methods A total of 120 patients with myasthenia gravis treated in our hospital from February 2016 to February 2018 were selected as subjects.According to the computer randomization method,the patients were divided into control group and experimental group,60 cases in each group.The control group was treated with Glucocorticoids.The experimental group was treated with Glucocorticoid combined with Cyclophosphamide.The respiratory function,serum indicators,clinical symptom score,clinical treatment effect and adverse reactions of the two groups were analyzed.Results The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P＜0.05).The clinical symptom scores of the experimental group were lower than those of the control group,the differences were statistically significant(P＜0.05).The respiratory muscle endurance,vital capacity and maximum ventilation of the experimental group were higher than those in the control group,but the myasthenic level was lower than that in the control group,the differences were statistically significant(P＜0.05).The interleukin-18(IL-18)level in the experimental group was lower than that in the control group,and the transforming growth factor-β1 (TGF-β1)level was higher than that in the control group,the differences were statistically significant(P＜0.05).The difference in total incidence of adverse reactions was not statistically significant between the two groups(P＞0.05).Conclusion Glucocorticoid combined with Cyclophosphamide in the treatment of myasthenia gravis can not only improve the patient′s respiratory function and serum indicators,but also relieve the clinical symptoms and signs with high safety,thus is worthy to be promoted.
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