Abstract：Objective To study the clinical effect of Alprostadil in the treatment of chronic renal failure(CRF).Methods Sixty-six patients with CRF admitted from December 2016 to December 2017 were enrolled as study subjects.The participants were divided into control group (n=33)and experimental group (n=33)according to the odd or even number.In the control group,conventional drug was used,while in the experimental group,Alprostadil was adopted.The therapeutic effect,renal function indicators before and after treatment,24 h urine protein,blood rheology indicators before and after treatment were compared in the two groups.Results After 14-day drug treatment,the total therapeutic effectiveness rate of the experimental group was 81.82%,which was higher than that of control group (63.64%)with a significant difference(P＜0.05).The renal function indicators such as blood urea nitrogen(BUN),serum creatinine(SCr)and 24 h urine protein after treatment in the experimental group were all lower compared with those before treatment,creatinine clearance rate(Ccr)was higher compared with before treament with significant differences(P＜0.05).The renal function indicators such as BUN,SCr and 24 h urine protein after treatment in the experimental group were lower compared with those of the control group,Ccr was higher than that in the control group with statistical significance(P＜0.05).The blood rheology indicators such as the whole blood low-shear viscosity,whole blood high-shear viscosity,blood cell aggregation index,blood viscosity,haematocrit,erythrocyte deformation index after treatment in the experimental group were lower compared with those before treatment(P＜0.05).The above-mentioned blood rheology indicators in the experimental group after treatment were lower compared with those in the control group with statistical significance (P＜0.05).Conclusion The treatment of Alprostadil in patients with CRF can improve patient′s renal function and hemorheology indicators,which is worthy of promotion and application.
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