Meta analysis of TLR2 Arg753Gln and CD14-159C/T polymorphisms and susceptibility to Streptococcus pneumoniae disease
ZHU Man-gui1 FENG Yan1 LI Xia-xi2▲
1.Department of Critical Care Medicine,Shunde Hospital,Guangzhou University of Chinese Medicine,Guangdong Province,Foshan 528300,China;
2.Department of Gastroenterology,Shenzhen Hospital,Southern Medical University,Guangdong Province,Shenzhen 518000,China
Abstract：Objective To investigate the association between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease.MethodsPubmed,embase,Cohrance,CNKI,VIP,Wanfang Data were searched to get related clinical controlled trials.The time limit for retrieving studies was until June 1,2017.Meta-analysis was conducted by Revman 5.3 software.Results Three TLR2 related papers were included,with a total sample size of 951 cases.Two CD14 related studies were included,with a total sample size of 674 cases.Meta-analysis showed no correlation between Arg753Gln polymorphism of TLR2 gene and CD14-159C/T polymorphism and susceptibility to Streptococcus pneumoniae disease(dominant allele vs.recessive alleles:OR=0.76,95%CI=0.40-1.46,P=0.41;dominant genotype vs.recessive genotype:OR=0.70,95%CI=0.34-1.44,P=0.33).Conclusion No significant differences between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease were found in the metaanalysis.
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