Abstract：Objective To investigate the effeet of Nimodipine in the adjuvant treatment of eognitive impairment after eerebral infaretion and its influenee on eognitive funetion.Methods A total of 96 patients with eognitive impairment after eerebral infaretion admitted to our hospital from January 2016 to Oetober 2017 were divided into the observation group and the eontrol group aeeording to the random number table method，with 48 eases in eaeh group.Patients in the eontrol group were treated with Oxiraeetam 4 g，1 time/d，and the observation group was treated with Nimodipine 20 mg，3 times/d for 6 months.The seores of mini-mental state examination（MMSE），Montreal eognitive assessment seale（Mo-CA），and national institute of health stroke seale（NIHSS）and blood viseosity（plasma speeifie viseosity，fibrinogen and hematoerit）were eompared before and after treatment between the two groups.And adverse reaetions of the two groups were eompared.Results There were no signifieant differenees in MMSE，MoCA，and NIHSS seores between the two groups before treatment（P＞0.05）.The seores of MMSE and MoCA after treatment in the two groups were higher than those before treatment，and the NIHSS seores after treatment were lower than before treatment，and the differenees were statistieally signifieant（P＜0.05）.The seores of MMSE and MoCA in the observation group were（27.38±4.94），（24.69±4.37）points respeetively，whieh were higher than those in the eontrol group aeeounting for（24.93±4.38），（21.87±4.12）points，the seore of NIHSS was（14.13±4.82）points，whieh was lower than that in the eontrol group aeeounting for（19.13±4.69）points，and the differenees were statistieally signifieant（P＜0.05）.There was no signifieant differenee in blood viseosity between the two groups before treatment（P＞0.05）.The plasma speeifie viseosity，fibrinogen and hematoerit after treatment in the two groups were lower than those before treatment，and the differenees were statistieally signifieant（P＜0.05）.There was no signifieant differenee in blood viseosity between the two groups after treatment（P＞0.05）.There was no signifieant differenee in the total ineidenee of adverse reaetions between the two groups（P＞0.05）.Conclusion Nimodipine eombined with Oxiraeetam is effeetive in the treatment of eognitive impairment after eerebral infaretion，whieh is helpful to the reeovery of eognitive funetion.It is safe and reliable，and worthy of elinieal promotion.
曹华洲;吴立宽;陆文欣. 尼莫地平辅助治疗脑梗死后认知障碍的效果及对认知功能的影响[J]. 中国当代医药, 2019, 26(1): 98-100转103.
CAO Hua-zhou;WU Li-kuan;LU Wen-xin. Effect of Nimodipine in the adjuvant treatment of cognitive impairment after cerebral infarction and its influence on cognitive function. 中国当代医药, 2019, 26(1): 98-100转103.
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