Abstract:Objective To compare the clinical effects of Ketamine combined with Midazolam and Propofol in pediatric anesthesia.Methods A total of 72 cases of children′s elective operation at ASAⅠ~Ⅱ level in our hospital from January 2017 to January 2018 were randomly divided into Ketamine+Midazolam group and Ketamine+Propofol group according to the method of anesthesia,36 cases in each group.The effects of two anesthesia methods on the heart rate and mean arterial pressure of children,as well as anesthesia induction,awakening time and body movement were compared.Results The awakening time of children in Ketamine+Propofol group was significantly shorter than that of Ketamine+Midazolam group(P<0.05),and the number of body movement was significantly lesser than that of Ketamine+Midazolam group during the anesthesia(P<0.05).The heart rate of the children in the Ketamine+Midazolam group was lower than that before anaesthesia,and the MAP was significantly higher than that before anesthesia,and the differences were statistically significant(P<0.05),but the heart rate and the MAP of the Ketamine+Propofol group had no significant changes(P>0.05).The incidence of adverse reactions in Ketamine+Propofol group was 9.37%,which was significantly lower than that in Ketamine+Midazolam group of 18.75%,the difference was statistically significant(P<0.05).Conclusion Ketamine combined Propofol anesthesia has better clinical effect,and it has worthy of clinical promotion.
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