Analysis of the effect of Alprostadil in the treatment of elderly patients with diabetes and chronic kidney disease
PENG Xiang-hang1 CHEN Zhen-hua2 QIU Yu1 CHEN Xin-yu1 LIU Hui-dan1
1.Department of Endocrinology,Changping Hospital in Dongguan City,Guangdong Province,Dongguan 523600,China;
2.Department of Endocrinology,Zhangmutou Hospital in Dongguan City,Guangdong Province,Dongguan 523633,China
摘要目的探讨前列地尔治疗高龄糖尿病合并慢性肾脏病患者的临床效果。方法选取2016年10月25日～2017年10月25日东莞市常平医院收治的58例高龄糖尿病合并慢性肾脏病患者作为研究对象，依据随机抽样分组原则将其分为对照组和观察组，每组各29例。对照组患者采用常规治疗方法，观察组患者则在常规治疗的基础上给予前列地尔治疗。比较两组患者的临床疗效、血肌酐（Cr）、24 h尿白蛋白排泄率（24 h UAER）、胱抑素C、血肌酐清除率（Ccr）水平和不良反应发生情况等。结果 治疗后，观察组患者的Cr、24 h UAER及胱抑素C低于对照组，Ccr高于对照组，差异有统计学意义 （P＜0.05）。观察组患者的临床治疗总有效率为93.1%，明显高于对照组（68.97%），差异有统计学意义（P＜0.05）。两组患者的不良反应发生情况比较，差异无统计学意义（P＞0.05）。结论在临床上，高龄糖尿病合并慢性肾病患者在常规治疗的同时给予一定剂量的前列地尔进行治疗，有利于提高患者的临床疗效，改善生活质量。
Abstract：Objective To investigate the clinical efficacy of Alprostadil in the treatment of elderly patients with diabetes and chronic kidney disease.Methods A total of 58 elderly patients with diabetes and chronic kidney disease treated in Changping Hospital in Dongguan City from October 25,2016 to October 25,2017 were selected as subjects.They were divided into control group and observation group according to the principle of random sampling,29 cases in each group.The patienys in control group were treated with conventional treatment,and the patients in observation group were given Alprostadil on basis of routine treatment.The clinical efficacy,serum creatinine(Cr),24 h urinary albumin excretion rate(24 h UAER),cystatin C,serum creatinine clearance rate (Ccr)levels and adverse reactions were compared between the two groups.Results After treatment,the Cr,24 h UAER and cystatin C in the observation group were lower than those in the control group,and the Ccr was higher than that in the control group,the differences were statistically significant(P＜0.05).The total effective rate of clinical treatment in the observation group was 93.1%,which was significantly higher than that in the control group(68.97%),and the difference was statistically significant(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion In clinic,elderly patients with diabetes and chronic kidney disease can be treated with a certain dose of Alprostadil at the same time of routine treatment,which can improve the clinical efficacy and quality of life.
彭湘杭；陈振华；邱宇；陈鑫瑜；刘惠丹. 前列地尔治疗高龄糖尿病合并慢性肾脏病患者的效果分析[J]. 中国当代医药, 2018, 25(14): 129-131.
PENG Xiang-hang；CHEN Zhen-hua；QIU Yu；CHEN Xin-yu；LIU Hui-dan. Analysis of the effect of Alprostadil in the treatment of elderly patients with diabetes and chronic kidney disease. 中国当代医药, 2018, 25(14): 129-131.
Sagara M，Suzuki K，Aoki C，et al.Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease：a case-control study[J].Car Dia，2016，15（1）：1-10.
Schneider C，Coll B，Jick SS，et al.Doubling of serum creatinine and the risk of cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes mellitus：a cohort study[J].Cli Epi，2016，8（1）：177-184.
京公网安备 11010502046607号