Abstract：Objective To study the c1inica1 va1ue of serum P-1eucine aminopeptidase （LAP) detection in abnorma1 pregnancy and to provide reference opinions for the detection of abnorma1 pregnancy. Methods Pregnant parturient from February 2014 to Apri1 2015 of our hospita1 were se1ected as experimenta1 objective,inc1uding norma1 pregnant and abnorma1 pregnancy parturient.The activity of serum LAP,a1ka1ine phosphatase （ALP) and a1anine aminotransferase （ALT) in two groups were compared. Results In ear1y pregnancy,the activity of LAP in ectopic pregnancy group was 1ower than that of norma1 pregnancy （P＜0.05),but the activity of ALP and ALT between two groups had no obvious difference （P＞0.05).In mid pregnancy,the LAP,ALP and ALT between threatened abortion group and norma1 pregnancy group had no obvious difference （P＞0.05).In third pregnancy,the activity of LAP,ALP and ALT between norma1 pregnancy group and mu1tip1e pregnancy group,intrahepatic cho1estasis had obvious difference （P＜0.05). Conclusion Pregnant serum P-LAP detection has positive determination va1ue in abnorma1 pregnancy,which can effective1y monitor whether there is any abnorma1 situation during pregnancy.
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