Abstract：Objective To investigate the therapeutic effect of methotrexate combined with sodium hyaluronate injection in the treatment of osteoarthritis.Methods 72 patients with osteoarthritis in our hospital from February 2014 to February 2015 were randomly divided into observation group（36 cases）and control group（36 cases），the observation group was treated with methotrexate combined with sodium hyaluronate injection，the control group was treated with sodium hyaluronate injection，the clinical efficacy of two groups were compared.Results The total efficiency of the observation group was 88.9%，significantly higher than 72.2%in the control group，the difference was statistically significant（P＜0.05）.After treatment，the VAS scores of the two groups was significantly lower than that of before treatment respectively，the difference was statistically significant（P＜0.05）.The VAS score of the observation group after treatment was lower than that of the control group，the difference was statistically significant（P＜0.05）.The incidence of adverse reactions in the observation group and control group was respectively 27.8%and 25.0%，the difference was not statistically significant（P＞0.05）.Conclusion The treatment of methotrexate combined with sodium hyaluronate injection patients with osteoarthritis is helpful to improve the clinical symptoms，the curative effect is remarkable.It is worth to be popularized in clinical application.
宋丽丽;朱立强;杜娟. 注射用甲氨蝶呤联合玻璃酸钠注射液治疗骨性关节炎的临床效果[J]. 中国当代医药, 2016, 23(16): 137-139.
SONG Li-li;ZHU Li-qiang;DU Juan. The clinical effects of methotrexate for Injection and sodium hyaluronate injection in treating osteoarthritis. 中国当代医药, 2016, 23(16): 137-139.
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