Abstract：Objective To observe the clinical effect and safety of intravenous injection of esmolol in the treatment of rapid supraventricular arrhythmia.Methods 100 patients with rapid supraventricular arrhythmia treated from January 2013 to December 2015 in our hospital were selected.The subjects were randomly divided into control group and observation group，50 cases in each group.The control group took diltiazem；the observation group took esmolol.The index of diastolic blood pressure，systolic blood pressure，heart rate as well as the clinical effect and adverse reactions for two groups were compared.Results After treatment，the index of diastolic blood pressure，systolic blood pressure，heart rate for observation group was even better than that of control group respectively（P＜0.05）；the clinical effective rate of observation group（94.0%）was significantly higher than that of control group（68.0%）（P＜0.05）；the incidence rate of adverse reactions like hypoglycemia，palpitation，nausea for two groups was not significantly different（P＞0.05）.Conclusion The intravenous injection of esmolol has an obvious effect and higher safety in patients with rapid supraventricular arrhythmia，can rapidly improve the patients′heart rate and blood pressure.It is worthy of clinical promotion.
周志堂. 静脉应用艾司洛尔治疗快速室上性心律失常的疗效和安全性[J]. 中国当代医药, 2016, 23(16): 134-136.
ZHOU Zhi-tang. Clinical effect and safety of intravenous injection of esmolol in the treatment of rapid supraventricular arrhythmia. 中国当代医药, 2016, 23(16): 134-136.
，观察组静脉应用艾司洛尔治疗。比较两组患者用药前后的心率、收缩压、舒张压等指标的变化情况；比较两组的临床效果；比较两组用药后的不良反应发生情况。结果 两组用药后的心率、收缩压、舒张压等指标均有改善，且观察组用药后的心率、收缩压、舒张压等指标显著优于对照组，差异有统计学意义（P＜0.05）；观察组的临床总有效率为94.0%，高于对照组的68.0%，差异有统计学意义（P＜0.05）；观察组发生低血糖、心悸、恶心等不良反应情况与对照组比较，差异无统计学意义（P＞0.05）。结论 静脉应用艾司洛尔治疗快速室上性心律失常患者可迅速改善患者的心率及血压水平，安全性高、临床效果确切，值得临床推广。
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