Abstract：Objective To analyze the clinical effect of bilateral knee replacement simultaneous and unilateral knee replacement.Methods Seventy knee joint replacement patients admitted into our hospital from January 2012 to January 2015 were evenly divided into observation group and control group.They were separately provided with bilateral knee replacement simultaneous and unilateral knee replacement.The surgical relevant indexes，knee joint function before surgery and one year after surgery，and occurrence of postoperative complications were compared in the two groups. Results In the observation group，the amount of postoperative bleeding was（410.3±39.6）ml，which was much higher than that in the control group of（156.2±47.5）ml（t=24.3084，P＜0.01）.The ΔHb within three days after surgery was（40.9± 11.6）g/L in the observation group，which was greatly higher than that in the control group of（17.3±7.9）g/L（t=5.7329，P＜0.01）.The ΔHct in the observation group was（12.3±2.8）%，which was greatly higher than that in the control group of （8.1±2.4）% （t=6.7377，P＜0.01）.In the observation group，postoperative ROM，knee flexion degree，and HSS score were （117.8±3.5）°，（0.5±0.0）°，（92.5±14.7）points in comparison with those before surgery of（85.5±13.6）°，（12.8±5.0）°，（55.1± 20.6）points，with statistically significant differences（t=13.6073，10.0324，8.7431，P＜0.01）.In the control group，postoperative ROM，knee flexion degree，and HSS score were （118.3±2.9）°，（2.1±0.8）°，（81.3±15.2）points in comparison with those before surgery of （86.8±14.1）°，（13.1±5.9）°，（58.9±23.1）points.After comparison，improvement after surgery was great（t=12.9458，10.9300，4.7924，P＜0.01）.There was no difference in postoperative ROM （t=0.6508，P＞0.05）. The postoperative knee joint flexion degree and HSS score were both superior to those in the control group （t=4.5916，3.1335，P＜0.01）.The incidence of postoperative complications was 5.71%in the observation group，and the incidence was 11.43%in the control group，without a significant difference （χ2=0.1823，P＞0.05）.Conclusion Bilateral knee replacement simultaneous can obtain a better effect in higher safety compared with unilateral one，which is worthy of clinical application and promotion.
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