Abstract：ObjectiveTo analyze the application effect of cocktail after knee joint replacement.Methods60 patients underwent the unilateral total knee arthroplasty and 60 patients underwent the single knee replacement of knee joint in Department of Orthopaedics of the Second People′s Hospital of Dalian City from 2012 to 2016 were selected and they were divided into the two groups according to admission time,and there were 30 cases in each group.The observation group (admission after 2014)was given cocktail analgesia during operation,while the control group (admission before 2014)were not given any analgesic drugs during operation.NRS score of sicken knee at rest and during exercise after 24 h,48 h,3 d,7 d,14 d surgery and the incidence of adverse reaction were observed.ResultsFor total knee arthroplasty and single condylar joint replacement,NRS score at rest and during exercise after 24 h,48 h,3 d operation in the observation group were significantly lower than those of the control group,and there was a statistical difference (P＜0.05),and there was no statistical difference of NRS score at rest and during exercise after 7 d,14 d surgery between groups(P＞0.05).The incidence rate of adverse reaction the observation group after operation was lower than that of the control gorup,with statistically significant difference(P＜0.05).ConclusionAdopting cocktail therapy for postoperative analgesia in total knee arthroplasty and unicompartmental knee arthroplasty has definite analgesic effect,and the adverse reaction is fewer,the safety is higher,which can provide better choice for postoperative analgesia regimen in clinical work.
Westonsimons JS，Pandit H，Haliker V，et al.Intra-articular local anaesthetic on the day after surgery improves pain and patient satisfaction after unicompartmental knee replacement：a randomised controlled trial[J].Knee，2012，19（4）：352-355.
[5]
Frehill B，Crocombe AD，Agarwal Y，et al.Finite element assessment of block-augmented total knee arthroplasty[J].ComputMethodsBiomech Biomed Engin，2015，18（15）：1726-1736.
Nwachukwu BU，Bozic KJ，Schairer WW，et al.Current status of cost utility analyses in total joint arthroplasty：a systematic review[J].Clin Orthop Relat Res，2015，473（5）：1815-1827.
[9]
Skinner HB，Shintani EY.Resultsof a multimodal analgesic trim involving patients with total hip or total knee arthroplasty[J].Am J Orthop，2004，33（10）：85-92.
[11]
Garciaolmo D，Herreros D，Pascual I，et al.Expanded adiposederived stem cells for the treatment of complex perianal fistula：a phase Ⅱ clinical trial[J].Dis Colon Rectum，2009，52（1）：79-86.
[12]
Ashraf A，Raut VV，Canty SJ，et al.Pain control after primary total knee replacement.A prospective randomised controlled trial of local infiltration versus single shot femoral nerve block[J].Knee，2013，20（5）：324-327.
[13]
Horn BJ，Cien A，Reeves NP，et al.Femoral nerve block vs periarticular bupivacaine liposome injection after primary total knee arthroplasty：effecton patient outcomes[J].J Am Osteopath Assoc，2015，115（12）：714-719.
[14]
Golder FJ，Dax S，Baby SM，et al.Identification and characterization of GAL-021 as a novel breathing control modulator[J].Anesthesiology，2015，123（5）：1093-1104.
[15]
Shanwani A，Nor AM，Amri N.Ligation of the intersphincteric fistula tract（LIFT）：a sphincter-saving technique for fistula-in-ano[J].Dis Colon Rectum，2010，53（1）：39-42.
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