Abstract：Objective To exp1ore the change of serum 1ipid in patients with Kawasaki disease （KD）in the ear1y stage and recovery stage.Methods 120 cases diagnosed as KD in our hospita1 from October 2011 to Ju1y 2015 were se1ected and divided into the acute group and the recovery group according to the course of KD，and a11 patients were divided into the CAL group（25 cases）and the NCAL group（95 cases）according to the criteria of KD combined with coronary artery di1atation.Another 120 hea1thy chi1dren were se1ected as the norma1 contro1 group.The 1eve1 of trig1yceride（TG），tota1 cho1estero1（TC），1ow density 1ipoprotein cho1estero1（LDL-C）and high density 1ipoprotein cho1estero1（HDL-C）1eve1 among each group was compared.Results The 1eve1 of TC，HDL-C，LDL-C in the acute group was 1ower than that in the norma1 contro1 group and the recovery group，with significant difference （P＜0.05）.The 1eve1 of HDL-C in the recovery group was 1ower than that in the norma1 contro1 group，with significant difference（P=0.00）.The 1eve1 of TG in the recovery CAL group was 1ower than that in the NCAL group，with significant difference（P=0.00）.CRP and TG were positive1y corre1ated（r=0.21，P=0.02），CRP and HDL-C were negative1y corre1ated（r=-0.36，P=0.00）.ESR and TC，TG，LDL-C were positive1y corre1ated（r=0.25，0.19，0.20，P=0.00，0.03，0.03），ESR and HDL-C were negative1y corre1ated（r=-0.26，P=0.00）. Conclusion Chi1dren with KD in the acute phase and after that suffer from b1ood 1ipid disorder and ear1y b1ood 1ipid disorder，which may be the resu1t of systemic inf1ammatory response.The disorder of serum 1ipids metabo1ism in patients with KD may have a 1ong-term effect on the disease.The fo11ow-up of b1ood 1ipid and ear1y intervention shou1d be carried out as soon as possib1e in c1inic.
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