Abstract：Objective To explore the clinical efficacy of different dose of gammag lobulin in children with Kawasaki disease(KD).Methods Forty children with KD from February 2014 to December 2015 were selected and randomly divided into the control group and the observation group,with 20 cases in each group.The control group was treated with lowdose gamma globulin,while the observation group was treated with high dose gammag lobulin.The time of fever clearance and hospitalization,the incidence of coronary artery lesions,and the levels of C-reactionprotein(CRP)and procalcitonin(PCT)before and after treatment of children in two groups were compared.Results The time of fever clearance and hospitalization of children in the observation group[(21.37±2.85)h,(3.24±0.89)d]were shorter than those in the control group[(33.09±3.17)h,(4.98±1.15)d],the differences were statistically significant(P＜0.05);the incidence of coronary artery lesions after 1 year follow-up in the observation group(5.00%)was lower than that in the control group(30.00%),the difference was statistically significant(P＜0.05).After treatment,the levels of CPR and PCT of children in two groups were decreased,comnpared with those before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The application of high dose of gamma globulin has significant effect in children with KD,which can shorten the time of fever clearance and hospitalization,reduce coronary artery lesions and decrease the levels of CRP and PCT of children.It is worthy of clinical application.
黄王滨;欧秋燕;林冬丽. 不同剂量丙种球蛋白治疗川崎病的临床效果[J]. 中国当代医药, 2017, 24(8): 99-101.
HUANG Wang-bin;OU Qiu-yan;LIN Dong-li. Clinical efficacy of different dose of gamma globulin in children with Kawasaki Disease. 中国当代医药, 2017, 24(8): 99-101.
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