Abstract:Objective To investigate the clinical effect of combination of application of alprostadil and ganglioside in the treatment of ischemic stroke.Methods Altogether 90 cases of ischemic stroke patients admitted to the hospital from October 2013 to October 2015 were selected as the study subjects and randomly divided into control group and observation group and 45 cases in each group.Control group was treated with ganglioside;alprostadil was added to the treatment of observation group based on control group.Both group were treated continuously for 2 weeks to observe and compare the clinical efficacy,post-treatment neurological deficiency score(NDS),the activities of daily living(ADL)score and serum inflammatory factor of the two groups.Results The total efficacy rate of Observation Group was 95.56%,higher than 77.78%in control group with statistical difference(P<0.05).In contrast with control group,the ADL score of the patients in observation group were significantly increased,and the NDS score was significantly lower with statistical difference(P<0.01).The post-treatment serum levels of TNF-α,CRP and IL-6 in observation group were significantly lower than those in control group respectively with statistical difference(P<0.05).Conclusion The combination of application of alprostadil and ganglioside in the treatment of ischemic stroke shows good effect and it deserves recommendation.
张剑文;李海鹰. 前列地尔联合神经节苷脂治疗缺血性脑卒中的临床疗效分析[J]. 中国当代医药, 2016, 23(19): 150-152转155.
ZHANG Jian-wen;LI Hai-ying. Analysis of clinical efficacy of combination of application of alprostadil and ganglioside in the treatment of ischemic stroke. 中国当代医药, 2016, 23(19): 150-152转155.
Zeydan B,Benbir G,Uluduz D,et al.Arterial and venous thrombosis of the cerebral vasculature in GAPO syndrome[J].Am J Med Genet A,2014,164A(5):1284-1288.
[18]
Sjoblom MD,Busso VO,Linscott LL,et al.Postoperative cerebral arterial thrombosis following cranial surgery in an infant[J].Paediatr Anaesth,2013,23(11):1105-1106.
[19]
Lee M,Joo IS,Lee SJ,et al.Multiple cerebral arterial occlusions related to Mycoplasma pneumoniae infection[J].Neurol Sci,2013,34(4):565-568.
[20]
Liu JC,Huang HY,Hsu YT.Hyperthyroidism and thrombophilia in cerebral arterial and venous thrombosis:a case report and critical review[J].Neurologist,2015,19(2):53-55.