Abstract：Objective To explore the effect of early administration with enteral nutritional suspension（ENS）on stress and prognosis for patients with craniocerebral injury（CI）.Methods Ninty-four CI patients of Wengyuan people′s hospital were enrolled during from January 2013 to October 2014.The CI patients were randomly divided into the observation and control group（n=47 for each group）.All the CI patients were given conventional treatment and ENS was applied for the patients belonging to the observation group，but not for the control group.T test was used to compare the differences of systolic pressure（SBP），white blood cell（WBC），neutrophile granulocyte（NEU），blood glucose（Glu），Glasgow coma scale （GCS），neurologic impairment score（NIHSS）between the two groups.Rank-sum test was applied to compare the rates of acute gastric mucosal lesion（AGML）and death for the two groups.Results There was no difference of AGML rate，SBP，WBC，NEU，Glu in the time-point of emergency hospitalization between the two groups（P＞0.05），but AGML rates in the control group was significantly higher，whereas SBP，WBC，NEU and Glu was significantly lower than that in the observation group at 72 h after treatment respectively（all P＜0.05）.There was no statistical difference of GCS in the time-point of emergency hospitalization between the two groups（P＞0.05），but GCS in the observation group increased and was higher than that in the control group（P＜0.05）.The days to recover consciousness in the observation group was shorter that of the control group（P＜0.05）.There were 2 patients died in the observation group whereas 4 in the control group within 1 month after treatment，presenting the significant difference of mortality between the two groups（P＜0.05）.NIHSS of onemonth after treatment in the observation group was significantly lower than that in the control group（P＜0.05）.Conclusion Early application of enteral nutrition mixed suspension can help improve stress and progress，which is clinically significant for patients with craniocerebral injury.
华县龙;赖汝标;陈新玉. 早期应用肠内营养混悬液对缓解重型颅脑损伤患者应激及改善预后的作用[J]. 中国当代医药, 2016, 23(19): 26-28.
HUA Xian-long;LAI Ru-biao;CHEN Xin-yu. Effect of early administration with enteral nutritional suspension on stress and prognosis for patients with craniocerebral injury. 中国当代医药, 2016, 23(19): 26-28.
Nägeli M，Fasshauer M，Sommerfeld J，et al.Prolonged continuous intravenous infusion of the dipeptide L-alanine-L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury［J］.Crit Care，2014，18（4）：R139.
Horn SD，Kinikini M，Moore LW，et al.Enteral nutrition for patients with traumatic brain injury in the rehabilitation setting：associations with patient preinjury and injury chara cteristics and outcomes［J］.Arch Phys Med Rehabil，2015，96（8 Suppl）：S245-S255.
京公网安备 11010502046607号