Abstract：Objective To explore paclitaxel and nedaplatin chemotherapy sequential radiotherapy for advanced esophageal cancer clinical effect. Methods Select January 2014 and 2015 January in our hospital were advanced esophageal cancer patientswith 80 cases，and randomly divided into control group and observation group，each group of 40 cases.The control group treated with radiotherapy alone in the treatment，the observation group were given paclitaxel，nedaplatin chemotherapy sequential therapy，compared two groups of treatment effect and side reaction.Results In the observation group of short-term effective rate was 87.5%，control group of the short-term effective rate was 60.0%，the treatment efficiency of observation group is higher than that of control group，the difference has statistical Significant （P＜0.05）.In the observation group，the white blood cell count decreased，decreased platelet count，nausea and vomiting，liver function damage and oralmucositis incidence rate were 35.0%、22.5%、27.5%、7.5%、45.0%，the control group of white cell count decreased，platelet count decreased，nausea and vomiting，liver function damage and oralmucositis incidence were 67.5%，55.0%，70.0%，35.0%，77.5%.Observation group of toxic or adverse reaction occurred rate was significantly lower than that of control group，the difference is statistically significant（P＜0.05）；after one year follow-up observation group survival rate was 80.0%.The control group survival rate was 47.5%，the survival rate was higher than that of control group（P＜0.05）.Conclusion Paclitaxel，nedaplatin chemotherapy sequential radiotherapy for significantly advanced esophageal cancer clinical effect，less adverse reaction，it isworth clinical promotion.
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