胸苷合成酶表达在培美曲塞治疗晚期卵巢癌患者效果评估中的意义

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摘要目的探讨胸苷酸合成酶（TS）表达在培美曲塞治疗晚期复发卵巢癌患者效果评估中的意义。方法回顾性分析2010年7月～2014年7月我院80例接受培美曲塞联合奈达铂化疗的晚期复发卵巢癌患者，其中实验组为40例经免疫组化检测TS表达阴性的患者，对照组40例为未经TS酶检测，分析疗效。结果实验组：完全缓解（CR）2例，部分缓解（PR）21例，稳定（SD）8例，进展（PD）9例，对照组：CR 1例，PR 13例，SD 7例，PD 19例。实验组的总有效率、疾病控制率和1年生存率分别为57.5%、77.5%、60.0%，对照组分别是35.0%、52.5%、37.5%，两组差异有统计学意义（P＜0.05）。结论 TS可能成为预测晚期卵巢癌患者对培美曲塞敏感性的指标，TS表达阴性卵巢癌患者可能从含培美曲塞的化疗方案中获益。

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	胡永华
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	秦苑
	李定纲

关键词 ：胸苷酸合成酶, 培美曲塞, 卵巢癌, 奈达铂

Abstract：Objective To evaluate the significance ofthe thymidylate synthase(TS)expression in therapeutic effect evaluation of Pemetrexed in patients with advanced ovarion cancer.Methods Eighty patients with advanced recurrent ovarian cancer from July 2010 to July 2014 treated in our hospital were analyzed retrospectively,all of them were treated by Pemetrexed combined with Nedaplatin,the experimental group had 40 cases,their tumor tissue were detected by immunohistochemistry with TS negative expression,the control groups of 40 cases with unknown TS expression.The therapeutic effectwas analyzed.Results In experimental group,there were 2 cases achieved complete responses(CR)of the 40 cases, 21 cases achieved partial response(PR),8 cases achieved stable disease(SD)and 9 patients with progressive disease(PD), while in observation group,there was 1 case achieved CR of the 40 cases,13 cases achieved PR,7 cases achieved SD and 19 patients with PD,while in experimental group,the overall response rate,the disease control rate and one year survival rate were 57.5%,77.5%and 60.0%respectively,in observation group,it was 35.0%,52.5%,37.5%respectively,and there was a statistical difference between two groups(P＜0.05).Conclusion TS expression may serve as an indicator to predict the sensitivity of chemosensitivity to Pemetrexed in patients with advanced ovarian cancer,the negative expression of TS can benefit from chemotherapy with Pemetrexed.

Key words： Thymidylate synthase Pemetrexed Ovarian cancer Nedaplatin

作者简介: 胡永华（1983-），女，河南杞县人，硕士，主治医师，专业擅长：恶性肿瘤的综合治疗，晚期肿瘤的姑息性治疗

引用本文:

胡永华;范宇飞;秦苑;李定纲. 胸苷合成酶表达在培美曲塞治疗晚期卵巢癌患者效果评估中的意义[J]. 中国当代医药, 2017, 24(8): 75-77.
HU Yong-hua;FAN Yu-fei;QIN Yuan;LI Ding-gang. The significance of the thymidylate synthase expression in therapeutic effect evaluation of Pemetrexed treating patients with advanced ovarion cancer. 中国当代医药, 2017, 24(8): 75-77.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I8/75

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