The curative effect analysis of long-term home noninvasive positive pressure ventilation combined with tiotropium brom ide and seretide in treatment of patients with severe COPD in stable period
XU Jian-qiang DAIYue FENG Juan CAO Nian DAI Li-li YUAN Xia
Department of Respiratory Medicine，the Third Clinical Hospital of Three Gorges University Gezhouba Group Center Hospital in Hubei Province，Yichang 443002，China
Abstract：Objective To observe the effect of long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide in treatment of patients with severe stable COPD.Methods 178 cases of severe stable COPD patients discharge in our department of respiratory from January 2011 to June 2014 were selected as the research object and divided into control group and experimental group，with 89 cases in each group，patients in two groups were discharged from the hospital after using the general treatment in stable period，on basis of general treatment，patients in the experimental group were treated with long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide，and patients in the control group were treated with tiotropium bromide and seretide.Patientswere followed up for 1 year，and the respiratory function，blood gas analysis，times of hospitalization，sixminutes walk test（6MWT）.St.George life quality（SGRQ）score，Modified Version of the British Medical Research Council Respiratory Questionnaire （mMRC）of discharged from the hospital and 1 years followed-up were observed and compared.Results ThemMRC scores，6MWT，SGRQ score，times of hospitalization in the experimental group were significantly lower than those in the control group （P＜0.05）；The lung function and PaCO2，PaO2in the experimental group was significantly improved，and the differenceswere statistically significant（P＜0.05）.Conclusion Long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide can effectively improve the pulmonary function of patientswith severe COPD in stable period，significantly improve blood gas and the quality of life，less times of hospitalization，which isworthy of clinical promotion.
许建强； 代阅； 冯娟 ；曹念 ；代莉莉 ；袁峡. 家庭长期无创通气联合噻托溴铵、舒利迭治疗重度COPD稳定期患者的效果分析[J]. 中国当代医药, 2016, 23(23): 31-35.
XU Jian-qiang； DAIYue； FENG Juan； CAO Nian； DAI Li-li ；YUAN Xia. The curative effect analysis of long-term home noninvasive positive pressure ventilation combined with tiotropium brom ide and seretide in treatment of patients with severe COPD in stable period. 中国当代医药, 2016, 23(23): 31-35.
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