Abstract:Objective To explore the relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 80 patients with T2DM treated in Pingxiang People's Hospital between October 2019 and May 2020 were retrospectively analyzed. According to the active cytomegalovirus infection status, the patients were divided into observation group (positive cytomegalovirus infection, viral DNA load>500 copies/ml, n=18) and control group (negative cytomegalovirus infection, viral DNA load≤500 copies/ml, n=62). The T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+) and pancreatic islet function (fasting Cpeptide [Fins], fasting 2 h C-peptide [F2CP]) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between DNA load of active cytomegalovirus infection and levels of T lymphocyte subsets and pancreatic islet function. Results The level of CD4+cells and CD4+/CD8+in observation group were significantly lower than those in control group, while the level of CD8+ cells was higher than that in control group, the differences were statistically significcant (P<0.05). The levels of FCP and F2CP were lower in observation group than those in control group, the differences were statistically significcant (P<0.05). The DNA load of cytomegalovirus infection was negatively correlated with CD4+, CD4+/CD8+, Fins and ISI, and was positively correlated with CD8+level (P<0.05). Conclusion The DNA load of active cytomegalovirus infection is closely related to the T lymphocyte subsets of patients with T2DM. The more active cytomegalovirus in the body of patients, the greater the degree of body's immune imbalance and the more severe the islet function damage. It is necessary to take corresponding treatment methods to improve the cytomegalovirus infection status.
蔡丽娟;任妹;刘剑荣;潘幸. 活动性巨细胞病毒感染DNA载量与2型糖尿病患者T淋巴细胞亚群的关系[J]. 中国当代医药, 2021, 28(30): 161-163.
CAI Li-juan;REN Mei;LIU Jian-rong;PAN Xing. Relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus. 中国当代医药, 2021, 28(30): 161-163.