摘要目的 探讨空腹三酰甘油(TAG)与不同时间动脉粥样硬化指数(AI)的相关性。方法 选取2019年1月至12月于乌鲁木齐市中医医院门诊就诊的24 例2 型糖尿病(T2DM)患者,根据空腹TAG 水平将患者分为空腹TAG 增高组(n=10,空腹TAG>1.8 mmol/L)和TAG 正常组(n=14,空腹TAG≤1.8 mmol/L)。比较两组一般资料、动脉粥样硬化发生率、TAG 达峰时间、空腹、脂肪餐后2、4、6 h 血脂代谢[TAG、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)]、血糖、胰岛素、糖化血红蛋白(HbAlc)、C 肽、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA),分析TAG 与AI 相关性。结果 空腹TAG 增高组与空腹TAG 正常组TAG 达峰时间均在餐后4 h,空腹、餐后2、4、6 h TAG、TC 高于空腹TAG 正常组,差异有统计学意义(P<0.05);空腹TAG 增高组餐后2、4、6 h AI 高于空腹TAG正常组,差异有统计学意义(P<0.05)。空腹TAG 与空腹AI 呈正相关(r=0.552,P<0.05),餐后2 h TAG 与餐后2 h AI 呈正相关(r=0.868,P<0.05),餐后4 h TAG 与餐后4 h AI 呈正相关(r=0.710,P<0.05),餐后6 h TAG 与餐后6 h AI 呈正相关(r=0.767,P<0.05)。结论 T2DM 患者TAG 与AI 存在正相关关系,故早期明确T2DM 患者空腹与餐后TAG 水平,可为临床评估血脂代谢紊乱、判断动脉粥样硬化发生提供数据支持。
Abstract:Objective To investigate the correlation between fasting triacylglycerol (TAG) and atherosclerosis index (AI)at different times.Methods A total of 24 outpatients with type 2 diabetes mellitus(T2DM)in Traditional Chinese Medicine Hospital of Urumqi from January 2019 to December 2019 were selected. The patients were divided into fasting TAG increased group (n=10, fasting TAG>1.8 mmol/L) and fasting TAG normal group (n=14, fasting TAG≤1.8 mmol/L), according to fasting TAG level. The general data, incidence of atherosclerosis, peak time of TAG, lipids metabolism at fasting and 2, 4 and 6 hours after meal (TAG, total cholesterol [TC], low density lipoprotein [LDL-C] and high density lipoprotein [HDL-C]), blood glucose, insulin, glycosylated hemoglobin (HbA1c), C-Peptide, tumor necrosis factor-α (TNF-α)and malondialdehyde (MDA) were compared in the two group to analyze the correlation between TAG and AI. Results The peak time of both group was 4 hours after meal. The TAG and TC of fasting and postprandial 2, 4 and 6 hours in the fasting TAG increased group were higher than fasting TAG normal group with statistically significant difference (P<0.05). AI of postprandial 2, 4 and 6 hours in fasting TAG increased group was higher than fasting TAG normal group(P<0.05). Fasting TAG was positively correlated with fasting AI (r=0.552, P<0.05). Postprandial 2 hours TAG was positively associated with postprandial 2 hours AI (r=0.868, P<0.05). Postprandial 4 hours TAG was positively associated with postprandial 4 hours AI (r=0.710, P<0.05). Postprandial positive correlation of 6 hours TAG with postprandial 6 hours AI (r=0.767, P<0.05). Conclusion There is a positive correlation between TAG and AI in T2DM patients. Therefore, early detection of fasting and postprandial TAG levels in T2DM patients can provide data support for clinical evaluation of dyslipidemia and judgment of atherosclerosisThere is a positive correlation between TAG and AI in T2DM patients. Therefore, early detection of fasting and postprandial TAG levels in T2DM patients can provide data support for clinical evaluation of dyslipidemia and judgment of atherosclerosis.
王迪. 空腹三酰甘油与不同时间动脉粥样硬化指数的相关性[J]. 中国当代医药, 2021, 28(28): 79-84.
WANG Di. Correlation between fasting triacylglycerol and atherosclerosis index at different times. 中国当代医药, 2021, 28(28): 79-84.
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