炎症性肠病患者焦虑和抑郁的研究进展

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摘要炎症性肠病（IBD）包括克罗恩病和溃疡性结肠炎，以慢性复发性肠道炎症为特征。越来越多的证据显示IBD 患者常伴有焦虑抑郁症状，但具体机制仍不清楚。炎症反应、氧化和亚硝酸盐（O&NS）途径、色氨酸分解代谢产物（TRYCAT）途径和肠道菌群机制在IBD 伴发焦虑抑郁的发展中可能起着重要的作用。一些社会经济、环境、生理因素，如教育、饮食、性别和压力也可能影响疾病的发展。目前已经有一些针对IBD 伴发焦虑抑郁治疗的临床试验。本文主要从IBD 合并焦虑抑郁的流行病学特征、发病机制、危险因素和治疗研究进展进行综述。

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	王一波
	程浩
	嵇晴

关键词 ：炎症性肠病, 焦虑, 抑郁, 流行病学, 发病机制

Abstract：Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, was characterized by chronic relapsing intestinal inflammation. Accumulating evidence shows that IBD patients often suffered from anxiety and depression, but the specific mechanism is still unclear. It is thought that inflammatory response, oxidative and nitrosative stress (O&NS) pathways, tryptophan catabolite (TRYCAT) pathways and intestinal flora mechanism may play an important role in the development of anxiety and depression associated with IBD. Some socioeconomic, environment,physiological factors such as education, diet, gender, stress, etc. May have an effect on the development of the disease.Up to now, some clinical trials have been conducted for the treatment of anxiety and depression associated with IBD.The epidemiologic features, pathogenesis, risk factors, and treatment of anxiety and depression associated with IBD will be reviewed in this paper.

Key words： Inflammatory bowel disease Anxiety Depression Epidemiology Pathogenesis

引用本文:

王一波；程浩；嵇晴. 炎症性肠病患者焦虑和抑郁的研究进展[J]. 中国当代医药, 2021, 28(30): 40-44.
WANG Yi-bo；CHENG Hao；JI Qing. Research progress of anxiety and depression in patients with inflammatory bowel disease. 中国当代医药, 2021, 28(30): 40-44.

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