Research on the relationship between serum 25(OH)D3 level and metabolic syndrome in middle-aged and elderly people in Hulunbuir area
DING Li-ping1 SONG Li-gang1 LI Yi-xin2 LIU Zi-qi1 ZHOU Ming-shuang1 ZHOU Fei1 ZHANG Xue
1.Department of Endocrinology,Hulunbuir People′s Hospital(Hulunbuir Clinical Medical College,Inner Mongolia University for Nationalities),Inner Mongolia Autonomous Region,Hulunbuir 021008,China;
2.Department of Laboratory Medicine,Hulunbuir People′s Hospital(Hulunbuir Clinical Medical College,Inner Mongolia University for Nationalities),Inner Mongolia Autonomous Region,Hulunbuir 021008,China
Abstract:Objective To explore the relationship between serum 25-hydroxyvitamin D3[25(OH)D3]levels and metabolic syndrome(MS)in the elderly in Hulunbuir area.Methods A total of 2145 MS patients who were admitted to the Hulunbuir People′s Hospital of Inner Mongolia from January 2017 to August 2019 were selected as the observation group,and 684 non-MS patients treated in Hulunbuir People′s Hospital of Inner Mongolia during the same period were selected as the control group.The body mass index(BMI),systolic blood pressure,diastolic blood pressure,blood biochemical indexes[25(OH)D3,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),uric acid(UA),and glycated hemoglobin(HbA1c)]were compared between the two groups,the correlation between 25(OH)D3 in the observation group and BMI,systolic blood pressure,diastolic blood pressure and blood biochemical indexes was analyzed,and the 25(OH)D3 levels in the two groups were compared.Results The BMI,LDL-C,TC,TG,HbA1c,FBG,systolic blood pressure and diastolic blood pressure of in observation group were higher than those in control group,and 25(OH)D3 was lower than that in the control group,the differences were statistically significant(P<0.05); There were no significant differences in HDL-C and UA between the two groups(P>0.05).The 25(OH)D3 level in the observation group was negatively correlated with BMI,HbA1c,FBG,diastolic blood pressure,LDL-C and systolic blood pressure(P<0.05).The proportions of 25(OH)D3≤20 ng/mL and >20~30 ng/mL in observation group were higher than those in control group,and the proportions of 25(OH)D3> 30 ng/mL were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion The serum 25(OH)D3 level is relatively insufficient in the middle-aged and elderly MS patients in Hulunbuir area,and its level is closely related to BMI,HbAlc,FBG,diastolic blood pressure,LDL-C,and systolic blood pressure.The decrease of 25(OH)D3 level may be related to MS Happened related.
丁丽萍; 宋黎刚; 李一鑫;刘子琪;周明爽;周菲; 张雪. 呼伦贝尔地区中老年人血清25-羟维生素D3水平与代谢综合征的关系研究[J]. 中国当代医药, 2021, 28(22): 143-146.
DING Li-ping; SONG Li-gang; LI Yi-xin; LIU Zi-qi; ZHOU Ming-shuang; ZHOU Fei;ZHANG Xue. Research on the relationship between serum 25(OH)D3 level and metabolic syndrome in middle-aged and elderly people in Hulunbuir area. 中国当代医药, 2021, 28(22): 143-146.