社区获得性肺炎患儿血清维生素D水平研究

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摘要目的探讨社区获得性肺炎（CAP）患儿血清维生素D（VD）水平与病情严重程度及年龄的关系，以期为儿童CAP 的病情预测与评估及VD 的补充提供依据。方法选取2018年11月～2019年11月于承德市中心医院住院治疗的145 例CAP 患儿作为研究对象，根据病情的严重程度将其分为轻症肺炎组（100 例）和重症肺炎组（45例），根据年龄将其分为幼儿组（31 例）和学龄前组（114 例），分别对各组血清25-（OH）D 水平进行比较。结果 145 例CAP 患儿血清25-（OH）D 平均水平为（23.4±9.0）ng/mL，其中25-（OH）D 水平正常89 例（61.38%），不足26 例（17.93%），缺乏30 例（20.69%），严重缺乏0 例。轻症肺炎组血清25-（OH）D 水平高于重症肺炎组，重症肺炎组血清25-（OH）D 不足（含缺乏）检出率高于轻症肺炎组，差异有统计学意义（P＜0.05）。幼儿组血清25-（OH）D 水平高于学龄前组，差异有统计学意义（P＜0.05）。其中轻症肺炎幼儿组血清25-（OH）D 水平高于学龄前组，差异有统计学意义（P＜0.05），重症肺炎幼儿组血清25-（OH）D 水平与学龄前组比较，差异无统计学意义（P＞0.05）。结论重症CAP 患儿较轻症CAP 患儿血清VD 水平低，VD 水平可能与年龄有关。

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关键词 ：社区获得性肺炎, 维生素D, 儿童, 年龄

Abstract：Objective To investigate the relationship between serum vitamin D (VD) levels and severity and age of children with community-acquired pneumonia (CAP), so as to provide evidence for the prediction and assessment of the condition of CAP and the supplement of VD. Methods A total of 145 CAP children hospitalized in Chengde Central Hospital from November 2018 to November 2019 were selected as the research objects. According to the severity of the disease, they were divided into mild pneumonia group (100 cases) and severe pneumonia group (45 cases). According to the age, they were divided into infant group (31 cases) and preschool group (114 cases). Serum 25-(OH)D levels were compared in each group. Results The average serum 25-(OH)D level of 145 CAP patients was (23.4±9.0) ng/mL, among which the 25-(OH)D level was normal in 89 cases (61.38%), less in 26 cases (17.93%), deficient in 30 cases(20.69%), and severe deficient in 0 cases. The level of 25-(OH)D in the mild pneumonia group was higher than that in the severe pneumonia group,and the detection rate of 25-(OH)D deficiency(including deficiency)in the severe pneumonia group was higher than that in the mild pneumonia group, and the differences were statistically significant (P＜0.05). The serum level of 25-(OH)D in the infant group was higher than that in the preschool group, and the difference was statistically significant (P＜0.05). The level of 25-(OH)D in the infant group with mild pneumonia was higher than that of the preschool group, and the difference was statistically significant (P＜0.05). There was no significant difference in serum 25-(OH)D level between the children with severe pneumonia group and the preschool group (P＞0.05). Conclusion The serum VD level of children with severe CAP is lower than that of children with mild CAP, which may be related to age.

Key words： Community-acquired pneumonia Vitamin D Children Age

收稿日期: 2020-10-12

引用本文:

李贺；刘建英. 社区获得性肺炎患儿血清维生素D水平研究[J]. 中国当代医药, 2021, 28(12): 127-129.
LI He1 LIU Jian-ying2▲. Study on serum vitamin D levels in children with community-acquired pneumonia. 中国当代医药, 2021, 28(12): 127-129.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I12/127

[1]	Misra M，Pacaud D，Petryk A，et al.Vitamin D deficiency in children and its management：review of current knowledge and recommendations[J].Pediatrics，2008，122（2）：398-417.
[2]	杨茜，李元霞，贾鲲鹏，等.维生素D 缺乏与儿童感染性疾病[J].中国儿童保健杂志，2020，28（6）：653-656.
[3]	中华医学会儿科学分会呼吸学组，《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南（2013 修订）（上）[J].中华儿科杂志，2013，51（10）：745-752.
[4]	Rabello LS，Lisboa T，Soares M，et al.Personalized treatment of severe pneumonia in cancer patients[J].Expert Rev Anti Infect Ther，2015，13（11）：1319-1324.
[5]	Huang Y，Fu L，Yang Y.Age-related vitamin D deficiency is associated with the immune response in children with community-acquired pneumonia[J].J Nutr Sci Vitaminol（Tokyo），2017，63（1）：1-7.
[6]	中华医学会儿科学分会儿童保健学组，《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志，2010，48（7）：502-509.
[7]	Norman AW.From vitamin D to hormone D：Fundamentals of the vitamin D endocrine system essential for good health[J].Am J Clin Nutr，2008，88（2）：491S-499S.
[8]	杨振东，宋国维.维生素D 在儿童呼吸道感染中的作用研究进展[J].中华实用儿科临床杂志，2018，33（16）：1270-1274.
[9]	张晓丹，赵贝，李光慧，等.维生素D 缺乏与感染发生的相关性及其机制研究进展[J].中国药房，2018，29（5）：710-715.
[10]	Abhimanyu，Coussens AK.The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease[J].Photochem Photobiol Sci，2017，16（3）：314-338.
[11]	Vanherwegen AS，Gysemans C，Mathieu C.Vitamin D endocrinology on the cross -road between immunity and metabolism[J].Mol Cell Endocrinol，2017，453（9）：52-67.
[12]	Tintino SR，Morais-Tintino CD，Campina FF，et al.Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps[J].Excli J，2016，15（3）：15-22.
[13]	Siswanto S，Zuhriyah L，Handono K，et al.Mycobacterium tuberculosis DNA increases vitamin D receptor mRNA expression and the production of nitric oxide and cathelicidin in human monocytes[J].Malays J Med Sci，2015，22（3）：18-24.
[14]	杜秋影，于立君，范慧子，等.维生素D 缺乏与小婴儿毛细支气管炎发病的关系[J].实用儿科临床杂志，2011，26（4）：304-305.
[15]	邓永超，唐喜春，袁远宏，等.婴幼儿重症肺炎维生素D水平动态变化及相关性分析[J].中国当代儿科杂志，2018，20（11）：911-916.
[16]	陈益明，卢莎，王忠平，等.血清25-羟维生素D 水平与儿童呼吸道感染的相关性[J].中国妇幼保健，2018，33（19）：4432-4434.
[17]	杨海军.维生素D 营养状态对反复呼吸道感染儿童免疫功能的影响[J].山东医药，2016，56（1）：62-63.
[18]	Pludowski P，Holick MF，Grant WB，et al.Vitamin D supplementation guidelines[J].J Steroid Biochem Mol Biol，2018，175：125-135.