Abstract：Objective To study the clinical effect of restrictive fluid management in the treatment of patients with chronic obstructive pulmonary disease (COPD) complicated with type Ⅱrespiratory failure. Methods Totally 120 patients with COPD complicated with type Ⅱrespiratory failure admitted to Ji′an Hospital of Shanghai East Hospital from January 2019 to December 2020 were selected as the study subjects, and they were divided into observation group and control group according to the random number table method, with 60 cases in each group. The two groups were given conventional treatment, and patients in control group were given non-restrictive fluid management on the basis of conventional treatment, and patients in observation group were given restrictive fluid management on the basis of conventional treatment. The ventilation time and fluid replacement volume of the two groups were compared within 1 week of treatment. The blood gas indexes (partial pressure of carbon dioxide [PaCO2], arterial oxygen pressure [PaO2], blood oxygen saturation [SpO2], pH) and blood indexes (lactic acid [LA], N-terminal B-type natriuretic peptide [NT-proBNP])were compared between the two groups before treatment and after 1 week of treatment. Results Within 1 week of treatment, the ventilation time and fluid replacement volume in observation group were lower than those in control group,the differences were statistically significant(P＜0.05).After 1 week of treatment,the LA,NT-proBNP and PaCO2 of observation group were lower than those of control group, the differences were statistically significant (P＜0.05). The pH value, PaO2 and SpO2 of observation group after 1 week of treatment were higher than those of control group, the differences were statistically significant (P＜0.05). Conclusion Restrictive fluid management for patients with COPD complicated with type Ⅱrespiratory failure is beneficial to restore the normal blood gas levels and shorten the ventilation time.
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