Clinical effect of Chuankezhi injection combined with high flow humidified oxygen delivery device in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure
QIAN Xu-sheng LI Bi-fang TAO Hai-lan ZHU Bi-yuan LIAN Le-shen WANG Ying-kang GUO Wei-xing
Department of Pulmonary and Critical Care Medicine,Dongguan Hospital of Traditional Chinese Medicine,Guangdong Province,Dongguan 523000,China
Abstract：Objective To observe the clinical effect of Chuankezhi injection combined with high flow humidified oxygen delivery devices(AIRVO2)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure and its influence on inflammatory mediators and cellular immune status.Methods A total of 122 AECOPD patients with respiratory failure admitted to the Department of Pulmonary and Critical Care Medicine of Dongguan Hospital of Traditional Chinese Medicine from September 2019 to November 2020 were selected and divided into the treatment group and the control group according to random number table method,61 cases in each group,1 case left out in each group,and 60 cases completed in each group.The control group was given AIRVO2,anti infection,expectorant and bronchial relaxation according to the guidelines.The treatment group was given Chuankezhi Injection on the basis of the control group.And the course of treatment was 14 days in each group.The traditional Chinese medicine syndrome score,the total white blood cell(WBC)count,C-reactive protein(CRP),arterial blood pH value,arterial partial pressure of oxy-gen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)and peripheral blood interleukin-1β (IL-1β),analysis of interleukin-8 (IL-8)and T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)were observed before and after treatment between the two groups.Results There were no significant difference in the traditional Chinese medicine syndrome score,the levels of WBC,CRP,pH value,PaO2,PaCO2,IL-1β,IL-8 and T lymphocyte subsets before treatment between the two group (P＞0.05).After treatment,the levels of WBC,CRP,PaCO2,IL-1β,IL-8 and CD8+in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of pH value,PaO2,CD3+,CD4+,CD4+/CD8+in the two groups were higher than those before treatment,and the differences were statistically significant(P＜0.05).The levels of WBC,CRP,PaCO2,IL-1β,IL-8 and CD8+in the treatment group after treatment were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of pH value,PaO2,CD3+,CD4+,CD4+/CD8+of the treatment group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Chuankezhi injection combined with AIRVO2can significantly improve the clinical effect of AECOPD with respiratory failure,and improve the inflammatory response and cellular immune status of patients.
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