Abstract： Objective To explore the effect of Cyclophosphamide combined with glucocorticoid in systemic lupus erythematosus (SLE).Methods A total of 82 SLE patients treated in Jiujiang First People′s Hospital from March 2018 to March 2020 were divided into observation group and control group according to the random number table method, with 41 cases in each group.The control group was treated with Prednisone, and the observation group was treated with Cyclophosphamide on the basis of the control group.The clinical efficacy, serum cytokine level, immunoglobulin level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in serum cytokine levels and immunoglobulin levels between the two groups before treatment (P＞0.05); after treatment, the interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-α (IFN-α), immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05); after treatment, the levels of IL-6, IL-10, IFN-α, IgA, IgM, and IgG in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Cyclophosphamide combined with Prednisone can enhance the therapeutic effect of SLE, reduce the body′s inflammatory response, suppress excessive immune hyperactivity, stabilize the progression of the disease, and is safe and reliable.
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