Abstract：objective To explore the role of clinical pharmacists in long-term treatment with Glucocorticoids patients through pharmaceutical care. Methods A total of 80 patients with nephrotic syndrome or systemic lupus erythematosus with long-term use of Glucocorticoids in Heyuan People′s Hospital from June 2018 to December 2019 were randomly selected. The patients with nephrotic syndrome and systemic lupus erythematosus in a 1∶1 way were divided into observation group (40 cases)and control group (40 cases) by random number table method. The control group received conventional treatment without clinical pharmaceutical care, and the observation group received conventional treatment with clinical pharmaceutical care, then the compliance, efficacy and adverse drug reactions between two groups were analyzed. Results Compared with the control group, the observation group had more understanding of the diseases,medicines and the drug compliance, the differences were statistically significant (P＜0.05). The renal function was improved, and the urinary protein decreased or negative urine patients were more than those in control group, the difference was statistically significant(P＜0.05). The main adverse drug reactions were Cushingoid features, with an incidence of more than 60%, but there was no significant difference between two groups (P＞0.05). However, the incidence of insomnia adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The clinical pharmacists participated in the pharmaceutical care of patients with long-term use of Glucocorticoids could promote their understanding of the diseases and medicines, drug compliance,improve renal function and reduce the occurrence of adverse reactions such as insomnia.
曾燕聪；黄双英；吴娣. 临床药师参与长期使用糖皮质激素患者药学监护的效果分析[J]. 中国当代医药, 2021, 28(3): 17-20.
ZENG Yan-cong ；HUANG Shuang-ying ；WU Di. Effect analysis of clinical pharmacists participating in the pharmaceutical care of patients with long-term use of Glucocorticoids. 中国当代医药, 2021, 28(3): 17-20.
Calis KA，Hutchison LC，Elliot ME，et al．Healthy people 2010：challenges，opportunities，and a call to action for America′s pharmacists[J]．Pharmacotherapy，2004，24（9）：1241-1294．
Morisky DE，Green LW，Levine DM．Concurrent and predictive validity of a self-reported measure of medication adherence[J]．Medical Care，1986，24（1）：67-74．
[11]
Patel DA，Kristensen PL，Pedersen-Bjergaard U，et al．Glucocorticoid-induced diabetes and risk factors during highdose therapy[J]．Ugeskr Laeger，2018，30；180（18）：V06170 454．
[12]
Waljee AK，Rogers MA，Lin P，et al．Short term use of oral corticosteroids and related harms among adults in the United States：population based cohort study[J]．BMJ，2017，357：j1415．
Rodenbeck A，Huether G，Rüther E，et al．Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia[J]．Neurosci Lett，2002，324（2）：159-163．
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