硫酸吗啡缓释片联合华蟾素胶囊治疗中晚期肝癌的临床效果

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摘要

目的探讨硫酸吗啡缓释片与华蟾素胶囊联合治疗方案在中晚期肝癌治疗中的临床有效性。方法选取2018年1月～2020年7月吉安市第一人民医院肿瘤科收治的60例中晚期肝癌患者作为分析对象，依据患者的就诊序号将其随机分为参照组（30例）和试验组（30例）。参照组患者采用常规化疗联合硫酸吗啡缓释片治疗，试验组采用常规化疗联合硫酸吗啡缓释片、华蟾素胶囊治疗。比较两组患者的治疗总有效率、Karnofsky 生活功能评估量表（KPS）、数字模拟疼痛简表中文译版（NRS）评分，比较两组患者的不良反应总发生率。结果试验组患者的治疗总有效率（93.33%）高于参照组（63.33%），差异有统计学意义（P＜0.05）；治疗前，两组患者的KPS、NRS评分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者的KPS评分高于治疗前，NRS评分低于治疗前，且试验组患者的KPS评分高于参照组，NRS评分低于参照组，差异有统计学意义（P＜0.05）；两组患者的不良反应总发生率比较，差异无统计学意义（P>0.05）。结论采用硫酸吗啡缓释片联合华蟾素胶囊治疗中晚期肝癌患者，对患者的功能恢复及疼痛缓解有显著增效，临床应用的不良反应较少，值得推广。

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	左晓春
	胡冬梅
	张艳

关键词 ：硫酸吗啡缓释片, 华蟾素胶囊, 中晚期肝癌, 疗效

Abstract：

Objective To investigate the clinical effectiveness of Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules in the treatment of advanced liver cancer.Methods A total of 60 patients with advanced liver cancer admitted to the Department of Oncology in the Ji′an First People′s Hospital from January 2018 to July 2020 were selected as the analysis subjects,and they were randomly divided into the reference group (30 cases) and the experimental group (30 cases) according to their serial numbers.The reference group was treated with routine chemotherapy combined with Morphine Sulfate Sustained Release Tablets.The experimental group was treated with routine chemotherapy combined with Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules.The total effective rate,Karnofsky life function assessment scale (KPS) and Chinese version of numeric rating analog pain scale(NRS) scores were compared between the two groups,and the total incidence of adverse reactions was compared between the two groups.Results The total effective rate of experimental group (93.33%)was higher than that of reference group (63.33%),and the difference was statistically significant (P＜0.05).Before treatment,there were no statistical significance in KPS and NRS scores between the two groups (P＞0.05).After treatment,the KPS scores of two groups were higher than those before treatment,the NRS scores of two groups were lower than those before treatment,the KPS score of experimental group was higher than that in the control group,and the NRS score of experimental group was lower than that in the control group,the differences were statistically significant (P＜0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules in the treatment of patients with advanced liver cancer has significantly enhanced the functional recovery and pain relief of patients,and has less adverse reactions in clinical application,which is worthy of promotion.

Key words： Morphine Sulfate Sustained Release Tablets Cinobufagin Capsules Advanced liver cancer Curative effect

基金资助:[基金项目]江西省吉安市科技计划项目

引用本文:

左晓春；胡冬梅；张艳. 硫酸吗啡缓释片联合华蟾素胶囊治疗中晚期肝癌的临床效果[J]. 中国当代医药, 2021, 28(7): 137-139转143.
ZUO Xiao-chun； HU Dong-mei； ZHANG Yan. Clinical effect of Morphine Sulfate Sustained Release Tablets combined with Cinobufagin Capsules in the treatment of advanced hepatocellular carcinoma. 中国当代医药, 2021, 28(7): 137-139转143.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I7/137

[1]	缪延栋，全无瑕.华蟾素胶囊治疗癌性疼痛患者的临床观察[J].中成药，2018，40（9）：2107-2110.
[2]	舒波，游川，刘福.华蟾素胶囊对中晚期癌症癌痛患者疼痛及生存质量的影响[J].中医药导报，2017，23（15）：48-50.
[3]	董雪山，李应宏，张宇杰，等.硫酸吗啡缓释片联合华蟾素胶囊治疗癌痛疗效观察[J].中国社区医师，2018，34（16）：84-85，87.
[4]	石芳毓，娄丽丽，谢吻，等.中药注射剂联合肝动脉插管栓塞化疗术治疗肝癌的网状Meta分析[J].中国实验方剂学杂志，2016，22（10）：180-187.
[5]	于晓强，柳杨.华蟾素胶囊联合内分泌药物辅助化疗治疗乳腺癌疗效及对血脂和免疫功能的影响[J].现代中西医结合杂志，2019，28（30）：3388-3390.
[6]	钟俐强，何杰，徐艳，等.华蟾素胶囊联合CapeOX 方案治疗老年晚期结直肠癌临床观察[J].实用老年医学，2019，33（11）：1123-1125.
[7]	刘文霞，吕金艳，王丽，等.盐酸羟考酮缓释片联合硫酸吗啡缓释片治疗晚期癌痛患者的疗效观察和护理体会[J].中国实用医药，2019，14（29）：108-110.
[8]	郑璐.盐酸羟考酮缓释片与硫酸吗啡缓释片治疗中重度癌痛患者的临床效果[J].医疗装备，2019，32（13）：102-103.
[9]	袁玉辉，马改改.氢吗啡酮与硫酸吗啡控释片对中重度癌症疼痛患者的镇痛效果对比[J].右江医学，2019，47（7）：520-522.
[10]	陆运松，寇玉彬，张龙龙，等.华蟾素对乳腺癌MDA-MB-231、MCF-7 细胞增殖及p-PTEN表达的影响[J].国际中医中药杂志，2019，41（12）：1338-1342.
[11]	金鑫，胡咏兵.超大剂量盐酸羟考酮缓释片与硫酸吗啡缓释片治疗重度癌痛对相关血清指标影响的对比研究[J].现代肿瘤医学，2019，27（1）：124-127.
[12]	廖胜祥，钟爱虹.硫酸吗啡缓释片治疗癌性疼痛的效果分析及对癌因性疲乏的影响[J].中外医学研究，2018，16（32）：31-33.
[13]	吴秋艳，赵明惠.盐酸羟考酮缓释片和硫酸吗啡缓释片治疗晚期恶性肿瘤重度疼痛的疗效及患者不良反应对比[J].临床医药文献电子杂志，2019，6（73）：164-165.
[14]	胡双莹.盐酸羟考酮与硫酸吗啡缓释片用于恶性肿瘤癌性疼痛治疗的临床效果比较[J].临床合理用药杂志，2019，12（11）：94-95.
[15]	吴丽明，金鹿，马继明，等.华蟾素胶囊、依托泊苷联合顺铂治疗老年非小细胞肺癌对患者炎症因子、血清肿瘤标志物的影响[J].海南医学，2020，31（1）：20-23.