米非司酮与曲普瑞林治疗子宫肌瘤的效果比较

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摘要目的比较米非司酮与曲普瑞林治疗子宫肌瘤的临床效果。方法选取2019年1～6月在沈阳市妇婴医院妇科治疗的60 例子宫肌瘤患者作为研究对象，根据随机数字表法将其分为观察组和对照组，每组各30 例。观察组患者应用米非司酮治疗，对照组患者应用曲普瑞林治疗。比较两组患者的疗效、肌瘤体积、血清激素和血红蛋白水平以及不良反应发生情况。结果观察组患者的治疗有效率高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者的肌瘤体积小于治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组患者的肌瘤体积小于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者的雌二醇（E2）、促卵泡激素（FSH）水平低于治疗前，血红蛋白水平高于治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组患者的E2、FSH 水平低于对照组，血红蛋白水平高于对照组，差异有统计学意义（P＜0.05）。观察组患者的不良反应总发生率低于对照组，差异有统计学意义（P＜0.05）。结论米非司酮可显著减小子宫肌瘤体积，降低E2、FSH 水平，升高血红蛋白水平，且不良反应较少，具有更显著的临床疗效。

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	王晓爽

关键词 ：米非司酮, 曲普瑞林, 子宫肌瘤, 疗效

Abstract：Objective To compare the effect of Mifepristone and Tripraline in the treatment of uterine fibroid.Methods A total of 60 patients with uterine fibroid who treated in Department of Gynaecology in Shenyang Women′s and Children′s Hospital from January to June in 2019 were selected as the research objects and divided into the observation group and the control group by random number table method,with 30 cases in each group.The observation group was treated with Mifepristone and the control group was treated with Tripraline.The treatment effect,fibroid volume,serum hormone and hemoglobin level and adverse reactions were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the fibroid volumes of the two groups were smaller than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the fibroid volume of the observation group was smaller than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of estradiol(E2)and follicle-stimulating hormone(FSH)in the two groups were lower than those before treatment,the level of hemoglobin was higher than that before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of E2 and FSH in the observation group were lower than those in the control group,the level of hemoglobin was higher than that in the control group,and the differences were statistically significant(P＜0.05).The total rate of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Mifepristone can significantly reduce the volume of uterine fibroids,reduce the levels of E2 and FSH,increase the level of hemoglobin,and the adverse reactions were less,with more significant clinical efficacy.

Key words： Mifepristone Triptorelin Uterine fibroid Treatment effect

收稿日期: 2020-04-09

引用本文:

王晓爽. 米非司酮与曲普瑞林治疗子宫肌瘤的效果比较[J]. 中国当代医药, 2021, 28(2): 91-93转97.
WANG Xiao-shuang. Effect comparison of Mifepristone and Tripraline in the treatment of uterine fibroid. 中国当代医药, 2021, 28(2): 91-93转97.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I2/91

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