Abstract：Objective To explore the predictive value of white blood cell (WBC) combined with neutrophil (N) levels and the occurrence of aggressive behavior in patients with first-episode schizophrenia. Methods A total of 60 patients with first-episode schizophrenia admitted to the Third People′s Hospital of Ji′an from July 2020 to December 2020 were selected as the research subjects. All patients were hospitalized for treatment for the first onset. According to the modified overt aggression scale (MOAS), they were divided into aggressive behavior group (n=30) and non-aggressive behavior group (n=30). The blood WBC and N levels of the two groups were compared, and the Pearson correlation coefficient test was used to analyze the blood WBC and N levels and the MOAS scale.The correlation of the scores of each item was analyzed by logistic regression to analyze the independent risk factors for the occurrence of aggressive behavior, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of blood WBC and N levels for the occurrence of aggressive behavior. Results WBC and N levels in the aggressive group were higher than those in the non-aggressive group. Pearson correlation analysis showed that WBC and N levels were positively correlated with the scores of verbal aggression, self-aggression, physical aggression and property aggression in MOAS.Logistic regression analysis showed that WBC (β=2.149, OR=8.551, 95%CI= 2.291-32.065) and N (β=1.961, OR=7.803,95%CI=1.208-15.318) levels were independent risk factors for aggressive behavior. The area under the curve (AUC) of attack behavior predicted by the two indexes was 0.906. Conclusion The blood WBC and N levels of first-episode schizophrenia patients with aggressive behavior are significantly increased. Both indicators are independent risk factors leading to the occurrence of aggressive behavior in patients. The combined evaluation of the two can accurately predict the occurrence of aggressive behavior, so that clinicians could conduct early intervention and treatment.
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