Abstract：Objective To study the clinical effect of Ziprasidone intramuscular injection in the treatment of acute schizophrenia.Methods A total of 120 patients with acute schizophrenia admitted to the Fourth People′s Hospital of Yingkou City from December 2017 to December 2019 were selected as the research subjects.According to the random number table method,they were divided into control group (60 cases) and research group (60 cases).The control group was treated with Haloperidol Injection,and the research group was treated with Ziprasidone Injection.The positive and negative symptom scale scores (PANSS),the total clinical effectiveness rate and the total incidence of clinical adverse reactions of the two groups before treatment and 72 hours after treatment were tested.Results The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score of the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.05).The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score before treatment between the two groups were compared,and the differences were not statistically significant (P>0.05).The total score of PANSS,positive factor score,negative factor score and the incidence of adverse reactions of the research group after treatment were all lower than those in the control group,and the differences were statistically significant (P<0.05).There was no statistical significance in the general psychopathological factor scores between the two groups after treatment (P>0.05).The total clinical effectiveness rate of the research group was higher than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Ziprasidone Injection has obvious clinical efficacy and high safety in patients with acute schizophrenia.Compared with Haloperidol Injection,the incidence of adverse reactions is lower,which is worthy of clinical reference.
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