Abstract:Kennedy′s disease is a rare nervous system degenerative disease,clinical performance because of its lack of specificity,It′s easy to misdiagnose and miss diagnosis.The diagnosis and differentiation of Kennedy′s disease were discussed through the neuroelectrophysiological changes and clinical characteristics.Genetic testing is still the gold standard for the diagnosis of Kennedy′s disease,which should be differentiated from amyotrophic laternal sclerosis in the early diagnosis.At present,there is no effective treatment for Kennedy′s disease,so early diagnosis and prevention are particularly important.In order to improve clinicians′ understanding of Kennedy′s disease,this article reviewed the clinical data of a patient with Kennedy′s disease who visited Zhongshan Hospital Affiliated to Dalian University from 2014 to 2020,analyzed the neuroelectrophysiology,clinical manifestations,diagnosis and treatment process,combined with literature review,emphasized the early differential diagnosis of Kennedy′s disease.
刘杰; 赵森. 肯尼迪病1例报道并文献复习[J]. 中国当代医药, 2021, 28(25): 215-217.
LIU Jie; ZHAO Sen. A case report of Kennedy's disease and literature review. 中国当代医药, 2021, 28(25): 215-217.
Rhodes LE,Freeman BK,Auh S,et al.Clinical features of spinal and bulbar muscular atrophy[J].Brain,2009,132(pt 12):3242-3251.
[2]
Grunseich C,Rinaldi C,Fischbeck KH.Spinal and bulbar muscular atrophy:pathogenesis and clinical management[J].Oral Dis,2014,20(1):6-9.
[3]
Kennedy WR,Alter M,Sung JH.Progressive proximal spinal and bulbar muscular atrophy of late onset.A sex-linked recessive trait[J].Neurology,1998,18(7):671-680.
[4]
Burgunder JM,Schols L,Baets J,et al.EFNS guidelines for the molecular diagnosis of neurogenetic disorders motoneuron,peripheral nerve and muscle disorders[J].Eur J Neurol,2011,18(2):207-217.