Abstract：Objective To investigate the effect of different doses of Pregabalin on postoperative pain undergoing radical resection of esophageal cancer under thoracoscopy. Methods A total of 120 patients underwent radical resection of esophageal cancer under thoracoscopy in the First Affiliated Hospital of Nanjing Medical University from January 2019 to January 2020 were selected as the research objects. The patients were divided into group P1 (low-dose pregabalin,30 cases), group P2 (medium-dose pregabalin, 30 cases), group P3 (high-dose pregabalin, 30 cases) and group C (no pregabalin, 30 cases) by random number table method. Patients in group P1 received orally Pregabalin concentration of 75 mg respectively, at 8 pm a night before surgery, 1 h before surgery and 6 h after surgery. Patients in group P2 received orally Pregabalin concentration of 150 mg respectively, at 8 pm a night before surgery, 1 h before surgery and 6 h after surgery. Patients in group P3 received orally Pregabalin concentrations of 300 mg respectively, at 8 pm a night before surgery, 1 h before surgery and 6 h after surgery, whereas group C received no oral analgesic drugs at the same scheme. The visual analogue score (VAS) in resting and cough state, Ramsay score in anaestheti-induced sedation(Ramsay), and 2 h after operation in the recovery room (T0), 2 h after operation (T1), 6 h after operation (T2), 12 h after operation (T3), 24 h after operation (T4) and 48 h after operation (T5), Pittsburgh Sleep Quality Index (PSQI) score, 48 h postoperative intravenous controlled analgesia pump (PCIA) dosage, dizziness, nausea and vomiting, visual impairment,pruritus, peripheral edema and other adverse reactions were compared. Results VAS scores in T0, T1, T2, T3, T4 and T5 in groups P1, P2 and P3 were lower than those in group C in resting and coughing state, and the differences were statistically significant (P<0.05). The Ramsay score be-fore induction of group P1, P2, P3 were lower than those of group C, and the differences were statistically significant(P<0.05). The PSQI score of group P1, P2, P3 were lower than those of group C, and the differences were statistically significant (P<0.05). The dosage of analgesics in PCIA of group P1, P2, P3 were lower than those of group C, the dosage of Group P2, P3 were lower than those of Group P1, the dosage of group P3 was lower than that of group P2,and the differences were statistically significant (P<0.05). The incidence of dizziness of group P3 was lower than that of group P1, P2, C, and the differences were statistically significant (P<0.05). Conclusion The application of Pregabalin in the radical surgery of thoracoscopic esophageal cancer can alleviate the postoperative pain, and oral administration of 150 mg Pregabalin is an effective and safe method for postoperative pain management after radical resection of esophageal cancer under thoracoscopy.
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