Research progress of non-motor symptom fluctuation in Parkinson′s disease
XIE Jin-jin1 KUANG Xiao-xiao1 KANG Ting-ting1 ZHANG Xue-yan1 KONG Fei-meng1 YANG Xiao-fan2▲
1.The Second Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157000,China;
2.Department of Rehabilitation Medicine,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157000,China
Abstract：Parkinson′s disease in addition to typical motor symptoms,there are many non-motor symptoms,such as constipation,depression,cognitive dysfunction and so on.Studies in recent years have found that non-motor symptoms also fluctuate,such as anxiety,depression,pain,cognition,etc.And many non-motor symptoms showed variations similar to movement fluctuations.Therefore,in the process of diagnosis and treatment,should not only pay attention to the fluctuation of patients′motor symptoms,but also pay attention to the fluctuation of patients′non-motor symptoms.This article mainly reviews the related studies of non-motor symptom fluctuation.
Ossig C，Sippel D，Fauser M，et al.Timing and Kinetics of Nonmotor Fluctuations in Advanced Parkinson′s Disease[J].J Parkinsons Dis，2017（2）：325-330.
[23]
Kleiner-Fisman G，Martine R，Lang AE，et al.Development of a non -motor fluctuation assessment instrument for Parkinson disease[J].Parkinsons Dis，2011，2011：292719.
[11]
Cheon SM，Park MJ，Kim WJ，et al.Non-motor off symptoms in Parkinson′s disease[J].Korean Med Sci，2009，24（2）：311-314.
Titova N，Padmakumar C，Lewis S，et al.Parkinson′s：a syndrome rather than a disease?[J].J Neural Transm（Vienna），2017，124（8）：907-914.
[2]
Storch A，Schneider CB，Wolz M，et al.Nonmotor fluctuations in Parkinson disease：severity and correlation with motor complications[J].Neurology，2013，80（9）：800-809.
[3]
Rodríguez V，Ospina G，Davila A，et al.Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson′s disease[J].Arq Neuropsiquiatria，2018，76（8）：517-521，
[4]
Witjas T，Kaphan E，Azulay JP，et al.Nonmotor fluctuations in Parkinson′s disease：frequent and disabling[J].Neurology，2002，59（3）：408-413.
[5]
Seki M，Takahashi K，Uematsu D，et al.Clinical features and varieties of non-motor fluctuations in Parkinson′s disease：a Japanese multicenter study[J].Parkinsonism Relat Disord，2013，19（1）：104-108.
[6]
Storch A，Schneider CB，Klingelhofer L，et al.Quantitative assessment of non-motor fluctuations in Parkinson′s disease using the Non-motor Symptoms Scale（NMSS）[J].J Neural Transm（Vienna），2015，122（12）：1673-1684.
[7]
Brun L，Lefaucheur R，Fetter D，et al.Non-motor fluctuations in Parkinson′s disease：prevalence，characteristics and management in a large cohort of parkinsonian outpatients[J].Clin Neurol Neurosurg，2014，127：93-96.
[8]
Picillo M，Palladino R，Moccia M，et al.Gender and non motor fluctuations in Parkinson′s disease：A prospective study[J].Parkinsonism Relat Disord，2016，27：89-92.
[9]
Martinez-Fernandez R，Schmitt E，Martinez-Martin P，et al.The hidden sister of motor fluctuations in Parkinson′s disease：a review on nonmotor fluctuations[J].Move Disord，2016，31（8）：1080-1094.
[10]
Chaudhuri KR，Sauerbier A，Rojo JM，et al.The burden of non-motor symptoms in Parkinson′s disease using a selfcompleted non-motor questionnaire：a simple grading system[J].Parkinsonism Relat Disord，2015，21（3）：287-291.
[12]
Rizos A，Martinez-Martin P，Odin P，et al.Characterizing motor and non-motor aspects of early-morning off periods in Parkinson′s disease：an international multicenter study[J].Parkinsonism Relat Disord，2014，20（11）：1231-1235.
[13]
Ossig C，Sippel D，Fauser M，et al.Assessment of nonmotor fluctuations using a diary in advanced Parkinson′s disease[J].Parkinsons Dis，2016，6（3）：597-607.
[14]
Maricle RA，Nutt JG，Valentine RJ，et al.Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson′s disease：a double-blind，placebo-controlled study[J].Neurology，1995，45（9）：1757-1760.
[16]
Fauser M，Lhle M，Ebersbach G，et al.Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson′s Disease[J].J Parkinsons Dis，2015，5（4）：737-741.
[18]
Gunal DI，Nurichalichi K，Tuncer N，et al.The clinical profile of nonmotor fluctuations in Parkinson′s disease patients[J].Can J Neurol Sci，2002，29（1）：61-64.
[19]
Iacono D，Geraci-Erck M，Rabin ML，et al.Parkinson disease and incidental Lewy body disease：Just a question of time?[J].Neurology，2015，85（19）：1670-1679.
[20]
Braak H，Del Tredici K，Rub U，et al.Staging of brain pathology related to sporadic Parkinson′s disease[J].Neurobiol Aging，2003，24（2）：197-211.
[21]
Braak H，de Vos RA，Bohl J，et al.Gastric alphasynuclein immunoreactive inclusions in Meissner′s and Auerbach′s plexuses in cases staged for Parkinson′s disease-related brain pathology[J].Neurosci Lett，2006，396（1）：67-72.
[22]
Levin OS，Ivanov AK，Shindriaeva NN.[Treatment of nonmotor fluctuations with combined drug stalevo in patients with Parkinson′s disease][J].Zh Nevrol Psikhiatr Im S S Korsakova，2011，111（1）：38-42.
[24]
Stacy M，Hauser R.Development of a Patient Questionnaire to facilitate recognition of motor and non-motor wearingoff in Parkinson′s disease[J].J Neural Transm（Vienna），2007，114（2）：211-217.
[25]
Stocchi F，Antonini A，Barone P，et al.Early detection of wearing off in Parkinson disease：the DEEP study[J].Parkinsonism Relat Disord，2014，20（2）：204-211.
京公网安备 11010502046607号