Effect comparison between Nimotuzumab combined with intensity-modulated radiotherapy and radiotherapy alone in the treatment of locally advanced nasopharyngeal carcinoma
ZHANG Xiao-xiao
Ward 12,Anshan Cancer Hospital,Liaoning Province,Anshan 114034,China
Abstract：Objective To compare the effect between Nimotuzumab combined with intensity-modulated radiotherapy(IMRT)and radiotherapy alone in the treatment of locally advanced nasopharyngeal carcinoma.Methods A total of 100 patients with locally advanced nasopharyngeal carcinoma who were admitted to Anshan Cancer Hospital from April 2015 to April 2017 were selected as the research subjects,and they were divided into the control group(50 cases)and the intervention group(50 cases)according to the random lottery method.Patients in the control group received IMRT alone,and patients in the intervention group were treated with Nimotuzumab for targeted therapy on the basis of IMRT.The therapeutic effect,survival period(overall survival [OS],progression-free survival [PFS]),quality of life,and incidence of adverse reactions were compared between the two groups.Results The total effective rate and disease control rate of the intervention group were higher than those of the control group,and the differences were statistically significant(P＜0.05).The OS and PFS of the intervention group were longer than those of the control group,and the quality of life score was higher than that of the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the intervention group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The effect of Nimotuzumab combined with IMRT is significantly better than that of radiotherapy alone in the treatment of locally advanced nasopharyngeal carcinoma.It can improve the local control rate,improve the quality of life of patients,and prolong their survival.It is worthy of popularization and application.
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