Abstract：Radiotherapy as the first choice of nasopharyngeal carcinoma treatment has been the focus of research.Radiotherapy is ofter considered as a local therapy and the improvement of its efficacy is affected by multiple factors.Cancer cells resistance to radiotherapy induced alternation of tumor microenvironment seriously affects the effectiveness of cancer treatment.Curcumin is a kind of natural plant extract with anti-tumor effect,which can interfere with the process of tumorigenesis and development from many aspects.Curcumin has many pharmacological functions,such as promoting cell apoptosis,blocking cell cycle,anti-inflammation,anti-metastasis,immunomodulation and so on.Recently,immunotherapy is widely investigated in clinical cancer treatment due to its highly targeting property and mild side effect,especially through modulating the functional phenotype of innate and adaptive immune cell to augment radiotherapy efficacy.The immunomodulatory effect of Curcumin can ameliorate the tumor microenvironment,which greatly improves the efficacy of radiotherapy.In this review,the research progress of Curcumin on tumorigenesis and development and its association with tumor radiation resistance are summarized as follows.
刘倩；刘英. 姜黄素在鼻咽癌放疗中抗癌机制的研究进展[J]. 中国当代医药, 2021, 28(5): 29-32.
LIU Qian；LIU Ying. Research progress on anticancer mechanism of Curcumin in radiotherapy for nasopharyngeal carcinoma. 中国当代医药, 2021, 28(5): 29-32.
Hesari A，Azizian M，Sheikh A，et al.Chemopreventive and therapeutic potential of curcumin in esophageal cancer：current and future status[J].Int J Cancer，2018，144（6）：1215-1226.
[2]
Badr G，Gul HI，Yamali C，et al.Curcumin analogue 1，5-bis（4-hydroxy-3-（（4-methylpiperazin-1-yl）methyl）phenyl）penta-1，4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells[J].Bioorg Chem，2018，78（78）：46-57.
[3]
Guo LD，Shen YQ，Zhao XH，et al.Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis[J].Phytother Res，2015，29（3）：357-365.
[4]
Banerjee S，Singh SK，Chowdhury I，et al.Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer[J].Front Biosci（Elite Ed），2017，9（1）：235-245.
[5]
Rivera M，Ramos Y，Rodriguez-Valentin M，et al.Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells[J].PLoS One，2017，12（6）：e179587-e179611.
[6]
Mortezaee K，Salehi E，Mirtavoos-Mahyari H，et al.Mechanisms of apoptosis modulation by curcumin：implications for cancer therapy[J].J Cell Physiol，2019，234（8）：12 537-12 550.
[7]
Zheng A，Li H，Wang X，et al.Anticancer effect of a curcumin derivative B63：ROS production and mitochondrial dysfunction[J].Curr Cancer Drug Targets，2014，14（2）：156-166.
Xiao TS.Innate immunity and inflammation[J].Cell Mol Immunol，2017，14（1）：1-3.
[23]
Kouhpeikar H，Butler AE，Bamian F，et al.Curcumin as a therapeutic agent in leukemia[J].J Cell Physiol，2019，234（8）：12 404-12 414.
[8]
Liu G，Xiang T，Wu QF，et al.Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19[J].Oncol Lett，2016，12（6）：5156-5162.
[9]
Zhang P，Lai ZL，Chen HF，et al.Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy，AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice[J].J Exp Clin Cancer Res，2017，36（1）：190-202.
[10]
Han SS，Chung ST，Robertson DA，et al.Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1，c-myc，bcl-XL，NF-κB，and p53[J].Clin Immunol，1999，93（2）：152-161.
[11]
Qu D，Shen L，Liu S，et al.Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer[J].Cancer Biol Ther，2017，18（4）：237-244.
[13]
Kunnumakkara AB，Sailo BL，Banik K，et al.Chronic diseases，inflammation，and spices：how are they linked?[J].J Transl Med，2018，16（1）：14-38.
[14]
Barchitta M，Maugeri A，Favara G，et al.Nutrition and wound healing：an overview focusing on the beneficial effects of Curcumin[J].Int J Mol Sci，2019，20（5）：1119-1132.
[15]
Sesarman A，Tefas L，Sylvester B，et al.Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes coencapsulating curcumin and doxorubicin on C26 murine colon cancer cells[J].Pharmacol Rep，2018，70（2）：331-339.
[16]
Pastorelli D，Fabricio A，Giovanis P，et al.Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine：results of a prospective phase Ⅱtrial[J].Pharmacol Res，2018，132（5）：72-79.
[17]
D′Ignazio L，Batie M，Rocha S.Hypoxia and inflammation in cancer，focus on HIF and NF-κB[J].Biomedicines，2017，5（2）：21-43.
[18]
Kim K，Punj V，Kim JM，et al.MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis[J].Genes Dev，2016，30（2）：208-219.
[19]
Gururaj AE，Belakavadi M，Venkatesh DA，et al.Molecular mechanisms of anti-angiogenic effect of curcumin[J].Biochem Biophys Res Commun，2002，297（4）：934-942.
[20]
Lin CY，Tsai PH，Kandaswami CC，et al.Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition[J].Cancer Sci，2011，102（4）：815-827.
[21]
Yang EV，Bane CM，Maccallum RC，et al.Stress-related modulation of matrix metalloproteinase expression[J].J Neuroimmunol，2002，133（1-2）：144-150.
[24]
Catanzaro M，Corsini E，Rosini M，et al.Immunomodulators Inspired by Nature：a Review on Curcumin and Echinacea[J].Molecules，2018，23（11）：2778-2794.
[25]
Rashid DR，Ali A，Ahmad SF，et al.Immunomodulatory effect of curcumin on lipopolysaccharide-and/or flagellininduced production of prostaglandin E2and relative expression of proinflammatory cytokines in the primary bubaline endometrial stromal cells[J].Reprod Domest Anim，2019，56（6）：917-923.
[26]
Mirzaei H，Shakeri A，Rashidi B，et al.Phytosomal curcumin：a review of pharmacokinetic，experimental and clinical studies[J].Biomed Pharmacother，2017，85（1）：102-112.
[27]
Ma W，Guo Q，Li Y，et al.Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy[J].Eur J Pharm Biopharm，2017，112（3）：209-223.
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