Abstract:Objective To compare the diagnostic value of two methods of human papillomavirus(HPV)typing and Cervista detection in cervical intraepithelial neoplasia(CIN).Methods A total of 106 women with CIN1 and 210 women with CIN2+diagnosed by new baishi liquid-based cytology(TCT)and confirmed by cervical biopsy in our hospital from January 2017 to December 2018 were enrolled in this study.All participants underwent HPV typing and Cervista testing simultaneously.Then the diagnostic effect of the two tests was compared.Results The overall coincidence rate of the two HPV testing methods was 87.34%(276/316),and the KIvalue was 0.6377.The positive rate of HPV typing in CIN1 group was 51.88%,which was higher than that of Cervista testing(33.96%),the difference was statistically significant(P<0.05),but there was no significant difference between the twomethods in the CIN2+group(P>0.05).Conclusion The two methods are in good consistency and have equivalent diagnostic value in cervical cancer screening.HPV typing test has a higher positive rate in CIN1.
范菊花; 秦艳; 宋春林. 人乳头瘤病毒分型与Cervista检测在宫颈内皮病变中的诊断价值[J]. 中国当代医药, 2020, 27(9): 135-137.
FAN Ju-hua; QIN Yan; SONG Chun-lin. Diagnostic value of human papillomavirus typing and Cervista detection in cervical intraepithelial neoplasia. 中国当代医药, 2020, 27(9): 135-137.
Schiffman M,Solomon D.Clinical practice.Cervical-cancer screening with human papillomavirus and cytologic cotesting[J].N Engl JMed,2013,369(24):2324-2331.
[5]
Li N,Franceschi S,Howell-Jones R,et al.Human papillomavirus type distribution in 30 848 invasive cervical cancers worldwide:Variation by geographical region,histological type and year of publication[J].Int JCancer,2011,128(4):927-935.
Arbyn M,Verdoodt F,Snijders PJ,et al.Accuracy of human papillomavirus testing on self-collected versus clinician collected samples:ameta-analysis[J].Lancet Oncol,2014,15(2):172-183.
[8]
Liu Y,Zhang L,Zhao G,et al.The clinical research of Thinprep Cytology Test(TCT)combined with HPV-DNA detection in screening cervical cancer[J].Cell Mol Biol(Noisyle-grand),2017,63(2):92-95.
Alameda F,Garrote L,Mojal S,et al.Cervista HPV HR test for cervical cancer screening:a comparative study in the Catalonian population[J].Arch Pathol Lab Med,2015,139(2):241-244.
[17]
Boers A,Slagter-Menkema L,van Hemel BM,et al.Comparing the Cervista HPV HR testand Hybrid Capture 2 assay in a Dutch screening population:improved specificity of the Cervista HPV HR test by changing the cut-off[J].PLoSOne,2017,9(7):e101930.