Abstract：[Abstract]Objective To investigate the clinical effect ofminimally invasive percutaneous nephrolithotomy（mPCNL）in the treatment of renal calculi.Methods A total of 106 patients with renal calculi admitted to our hospital from March 2018 to February 2019 were selected as research objects，and were divided into observation group and control group by random number table method，53 cases in each group.Patients in the observation group were treated with mPCNL，while patients in the control group were treated with standard channel percutaneous nephrolithotomy（SPCNL）.The disposable stone clearance rate，perioperative related indexes，pain，renal function indexes（β2-microglobulin [β2-MG]，urea nitrogen [BUN]，serum creatinine [Cr]）and complications were compared between the two groups.Results The intraoperative blood loss in the observation group（[107.63±22.19]ml）was less than that in the control group（[153.41±26.38]ml），the hospitalization time（[8.36±1.29]d）wass shorter than that in the control group（[12.36±1.87]d），and the visual analogue scale（VAS）score（[2.42±0.68]points）was lower than that in the control group（[3.36±0.79]points），the operation time（[129.64±20.53]min）was longer than that of the control group（[102.41±18.76]min），with statistically significant differences（P＜0.05）.Before operation，there were no significant difference in β2-MG，BUN and Cr levels between the two groups（P＞0.05）.After operation，the β2-MG（[2.13±0.80]ng/L），BUN（[8.37±2.13]mmol/L），Cr（[92.53±9.57]mmol/L）levels in the observation group were lower than those in the control group（[3.45±0.87]ng/L，[14.51±2.24]mmol/L，[106.92±10.43]mmol/L），the differences were statistically significants（P＜0.05）.The total incidence of complications in the observation group（3.77%）was lower than that in the control group（15.09%），and the difference was statistically significant（P＞0.05）.The removal rate of one-off stones in the observation group（90.57%）was not significantly different from that in the control group（86.79%）（P＞0.05）.Conclusion MPCNL has the advantages of less trauma，high stone clearance rate and fewer complications in the treatment of renal calculi，it can reduce postoperative pain，shorten hospitalization time，reduce renal damage and has clinical application and popularization value.
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