1. Department of Obstetrics，Kunming First People′s Hospital，Yunnan Province，Kunming 650011，China；
2. Department of Ultrasound. Kunming First People′s Hospital，Yunnan Province，Kunming 650011，China；
3. Department of Laboratory，Kunming First People Kunming Kunming′s Hospital，Yunnan Province，Kunming 650011，China
Abstract：Objective To explore the predictive value of cervical length and intercellular adhesion molecule-1 (ICAM-1) in serum of pregnant women. Methods A total of 241 parturients with single pregnancy in our hospital from January 2018 to October 2019 were selected. According to the pregnant state and the gestational age at delivery they were divided into healthy control group (n=90)，threatened preterm delivery group (n=88) and preterm delivery group (n=63).The cervical length and serum ICAM-1 concentration were measured in all the parturients. The above indexes of the three groups were compared to evaluate the predictive value of cervical length and ICAM-1 on preterm delivery. Results the cervical length of preterm delivery group was shorter than that of healthy control group and threatened preterm delivery group，and the serum ICAM-1 level of preterm delivery group was higher than that of the other two groups，with statistical differences (P＜0.05)； the positive rate of cervical length and serum ICAM-1 in preterm delivery group was higher than that of healthy control group (P＜0.05)； the sensitivity and negative predictive value of cervical length combined with serum ICAM-1 were higher than those of single index diagnosis. Conclusion The combination of cervical length and serum ICAM-1 has a high predictive value for the occurrence of preterm delivery in pregnant women，which is worthy of clinical application.
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