Relationship between blood pressure variability and target organ damage
LI Ke1,2 WANG Li1,2 LIU Jian-xiong2▲
1.Graduate School,Zunyi Medical University,Guizhou Province,Zunyi 563003,China;2.Department of Cardiology,the Second People′s Hospital of Chengdu City,Zunyi Medical University,Sichuan Province,Chengdu 610017,China
Abstract：Hypertension is a risk factor for many cardiovascular diseases.In some patients with well-controlled blood pressure,damages of target organs and cardiovascular adverse events may still occur.In 2013,ESC proposed that blood pressure variability should become a new important target in the field of blood pressure control.Hypertension is a risk factor for various target organ damages such as heart,brain and kidney.Blood pressure variability is a new target for the management of hypertension,and further control of blood pressure variability will effectively reduce the damage rate of important target organs throughout the body,as well as reduce the incidence rates of diseases including renal insufficiency,stroke,cognitive decline,ventricular hypertrophy,heart failure,arrhythmia,peripheral arteriosclerosis,and coronary heart disease.
Kario K.Prognosis in relation to blood pressure variability：pro side of the argument[J].Hypertension，2015，65（6）：1163-1169.
[7]
Wang J，Shi X，Ma C，et al.Visit-to-visit blood pressure variability is a risk factor for all-cause mortality and cardiovascular disease：a systematic review and meta-analysis[J].J Hypertens，2017，35（1）：10-17.
Yano Y，Fujimoto S，Kramer H，et al.Long-term blood pressure variability，new-onset diabetes mellitus，and new-onset chronic kidney disease in the japanese general population[J].Hypertension，2015，66（1）： 30-36.
[12]
Rabello CK，Ravizzoni DD，Moura M，et al.Increased vascular sympathetic modulation in mice with Mas receptor defi-ciency[J].J Renin Angiotensin Aldosterone Syst，2016，17（2）：1-5.
[13]
James PA，Oparil S，Carter BL，et al.2014 evidence-based guidelineforthemanagementofhighbloodpressureinadults：report from the panel members appointed to the Eighth Joint National Committee （JNC 8）[J].JAMA，2014，311（5）：507-520.
[14]
Yu JM，Kong QY，Schoenhagen P，et al.The prognostic value of long-term visit-to-visit blood pressure variability on stroke in real-world practice：a dynamic cohort study in a large representative sample of Chinese hypertensive population[J].Int J Cardiol，2014，177（3）：995-1000.
[16]
Bohm M，Schumacher H，Leong D，et al.Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk[J].Hypertension，2015，65（3）：651-661.
[17]
Yano Y，Ning H，Allen N，et al.Long-term blood pressure variability throughout young adulthood and cognitive function in midlife：the Coronary Artery Risk Development in Young Adults （CARDIA） study[J].Hypertension，2014，64（5）：983-988.
[18]
Ryu J，Cha RH，Kim DK，et al.The clinical association of the blood pressure variability with thetarget organ damage in hypertensive patients with chronic kidney disease[J].J Korean Med Sci，2014，29（7）：957-964.
[19]
Vishram JK，Dahlof B，Devereux RB，et al.Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage：a LIFE substudy[J].J Hypertens，2015，33（12）：2422-2430.
[20]
Tatasciore A，Zimarino M，Tommasi R，et al.Increased short-term blood pressure variability is associated with early left ventricular systolic dysfunctionin newly diagnosed untreated hypertensive patients[J].J Hypertens，2013，31（8）：1653-1661.
[21]
Jíra M，Závodná E，Nováková Z，et al.Reproducibility of blood pressure and inter-beat interval variability in man[J].Physiol Res，2010，59（1）：S113－S121.
[22]
Chen Y，Xiong H，Wu D，et al.Relationship of short-term blood pressure variability with carotid intima-media thickness in hypertensive patients[J].Biomed Eng Online，2015，14（1）：71.
[23]
Song H，Wei F，Liu Z，et al.Visit-to-visit variability in systolic blood pressure：correlated with the changes of arterial stiffness and myocardial perfusion in on-treated hypertensive patients[J].Clin Exp Hypertens，2015，37（1）：63-69.
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