Abstract：Objective To determine effect of different ways of administration of Misoprostol on the termination of the mid-trimester pregnancy (13-20 weeks).Methods A total of 252 cases of receiving termination of the mid-trimester pregnancy in our hospital from June 2014 to June 2015 were selected.They were randomly divided into oral administration group(OA group),sublingual administration group(SA group),and vaginal administration group(VA group),84 cases in each group.Three groups were given Mifepristone 75 mg every time in the morning and night in the first day and the second day,Misoprostol 600 μg in the third day morning respectively.The abortion effects,adverse reactions and acceptability between the three groups were analyzed.Results There was no statistical difference in the beginning time of the abdominal pain and number hemorrhage among three groups(P＞0.05).The complete abortion rate and success rates of abortion in 24 h of the VA group and SA group were statistically significant higher than OA group.The abortion time of OA group were significantly longer than that in the VA group and SA group.No statistically significant differences in the incidence of the side-effect including fever,headache and so on (P＞0.05).Oral administration and sublingual administration were more acceptable than that in the VA group,the difference was statistically significant(P＜0.05).Conclusion The vaginal administration and sublingual administration of Misoprostol on the termination of the mid-trimester pregnancy have many advantages：high complete abortion rate,short abortion time,high success rates of abortion in 24 h,fewer side-effects.And sublingual administration were more acceptable by patients.
侯峰;周平;邢佳玲. 米索前列醇不同给药途径在终止13～20周妊娠中的效果分析[J]. 中国当代医药, 2018, 25(23): 118-120.
HOU Feng;ZHOU Ping;XING Jia-ling. Effect analysis of different ways of administration of Misoprostol on termination of gestation for 13 to 20 weeks. 中国当代医药, 2018, 25(23): 118-120.
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