Abstract：Objective To analyze the risk factors of preterm premature rupture of membranes(PPROM).Methods A total of 105 PPROM patients who were examined in our hospital from July 2015 to February 2017 were selected as the study group.Meanwhile,100 healthy pregnant women without premature rupture of membranes during the same period were chosen as the control group.The general clinical data,interleukin-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),mean platelet volume(MPV),and procalcitonin(PCT)were compared in the two groups.The Logistic regression analysis was used to determine the factors affecting PPROM and the strengthen of effect of each index was demonstrated using the forest map.Results Compared with the control group,the levels of IL-6,IL-8,TNF-α,CRP,MVP,and PCT were all significantly increased in the study group,with a statistical difference (P＜0.05）.Multivariate regression analysis showed that the levels of IL-6,IL-8,TNF-α,CRP,MVP and PCT in peripheral blood were significantly associated with the occurrence of PPROM,with a statistical difference (P＜0.05）.Conclusion The levels of IL-6,IL-8,TNF-α,CRP,MVP and PCT in peripheral blood can be used to predict the risk of PPROM,which has certain clinical diagnostic value.
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