粪便隐血试验和转铁蛋白联合检测在诊断消化性出血中的意义

摘要
图/表
参考文献(16)
相关文章 (15)

全文: PDF (0 KB) HTML (33 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨粪便隐血试验联合转铁蛋白检测在消化性出血疾病中的诊断意义，为临床疾病诊治提供依据。方法选取2016年9月～2017年9月于我院就诊并经消化内镜及病理组织学确诊的消化性出血患者81例为观察组，按照出血位置不同分为上消化道出血组（51例）和下消化道出血组（30例），另选取同期于我院行健康体检的患者60例为对照组。以消化道内镜和病理组织学检测为金标准，判断粪便隐血试验和转铁蛋白检测的诊断意义。结果上消化道出血组粪便隐血实验检测阳性率（47.06%），转铁蛋白检测阳性率（50.98%），两者均显著低于联合检测阳性率（84.31%），差异有统计学意义（P＜0.05）。下消化道出血组粪便隐血试验检测阳性率（56.67%），转铁蛋白检测阳性率（63.33%），两者均显著低于联合检测阳性率（86.67%），差异有统计学意义（P＜0.05）。粪便隐血试验检测灵敏度（50.62%），转铁蛋白检测灵敏度（55.56%），两组均明显低于联合检测灵敏度（85.19%），差异有统计学意义（P＜0.05）。三种检测方式特异度均为98.33%。结论粪便隐血实验联合转铁蛋白检测诊断消化道出血疾病有较高诊断准确率，高灵敏度及特异度，利于患者早期诊治，值得临床推广应用。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	谭罗坤
	罗海顺
	伍尚剑
	李翠叶

关键词 ：粪便隐血实验, 转铁蛋白, 消化道出血, 诊断

Abstract：Objective To investigate the significance of fecal occult blood test combined transferrin detection in the diagnosis of digestive hemorrhage.Methods A total of 81 patients with digestive hemorrhage who were treated in our hospital from September 2016 to September 2017 were randomly selected as observation group.According to the location of the hemorrhage,they were divided into the upper gastrointestinal bleeding group (51 cases)and the lower gastrointestinal bleeding group(30 cases),and 60 patients who had a health examination in our hospital during the same period were selected as the control group.The diagnostic significance of fecal occult blood test and transferritin detection was determined by endoscopy and histopathological examination.Results The positive rate of upper gastrointestinal bleeding was 47.06%with fecal occult blood test,and the positive rate of transferrotein detection was 50.98%,both of which were significantly lower than the joint test(84.31%),with a statistical difference(P<0.05).The positive rate of fecal occult blood test in the lower gastrointestinal bleeding group was 56.67%.The positive rate of transferrotein detection was 63.33%,both of which were significantly lower than the joint test(86.67%),with a statistical difference(P<0.05).Fecal occult blood test alone the detection sensitivity was 50.62%,transferrin separate detection sensitivity was 55.56%,the two groups were significantly lower than 85.19%of joint detection,with a statistical difference(P<0.05).The specificity of the three methods were 98.33%.Conclusion The fecal occult blood test combined with transferrotein test for diagnosis and diagnosis of gastrointestinal hemorrhage has high diagnostic accuracy,high sensitivity and specificity,which is beneficial to the early diagnosis and treatment of patients,and it is worthy of clinical application.

Key words： Fecal occult blood experiment Transferrin Gastrointestinal bleeding Diagnose

作者简介: 谭罗坤（1977-），男，本科，主管技师，研究方向：临床检验

引用本文:

谭罗坤;罗海顺;伍尚剑;李翠叶. 粪便隐血试验和转铁蛋白联合检测在诊断消化性出血中的意义[J]. 中国当代医药, 2018, 25(21): 137-139.
TAN Luo-kun;LUO Hai-shun;WU Shang-jian;LI Cui-ye. The significance of fecal occult blood test combined transferrin detection in the diagnosis of digestive hemorrhage. 中国当代医药, 2018, 25(21): 137-139.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I21/137

[1]	滕娟，王欣.粪转铁蛋白和粪便隐血试验联合应用于消化道出血和肿瘤检测中的意义[J].中国卫生检验杂志，2017，27（1）：69-70.
[2]	汪建军，余艳丽，王一丹，等.显微镜检查胃液对上消化道出血诊断的临床价值[J].临床输血与检验，2016，18（6）：580-582.
[3]	Choi YA，Sang HY，Song YM，et al.Diagnostic utility of immunochemical fecal occult blood tests to detect lower gastrointestinal lesions in patients with chronic kidney disease[J].Int J Colorectal Dis，2015，30（7）：919-925.
[4]	程琴，张金生.转铁蛋白在验证大便少量或难辨认白细胞中的应用[J].检验医学与临床，2015，16（20）：3068-3069.
[5]	王萍，刘辉，张铁，等.体外模拟胃肠道消化环境对免疫法粪便隐血实验的影响[J].中华检验医学杂志，2017，40（4）：294-297.
[6]	Brenner H，Hoffmeister M，Birkner B，et al.Diagnostic performance of guaiac-based fecal occult blood test in routine screening： state-wide analysis from Bavaria，Germany[J].Am J Gastroenterol，2015，109（3）：427-435
[8]	王永志，王宏，申亚丽，等.三种检测方法在胃液隐血试验中的临床应用评价[J].现代检验医学杂志，2015，30（5）：135-137.
[9]	娄国平，李显东，张昭勇.联合检测粪便血红蛋白和转铁蛋白在肠癌疾病防治中的应用[J].检验医学与临床，2015，16（9）：1193-1195.
[10]	周刚，毕光宇，魏丛军，等.腹膜透析合并纯红细胞再生障碍性贫血一例[J].中国医师杂志，2016，18（S1）：216-217.
[7]	Sueta D，Hokimoto S，Tayama S，et al.Clinical significance of fecal occult blood screening in patients before percutaneous coronary intervention[J].Int J Cdiarol，2015，182：85-87.
[11]	杨勇文，李从荣，李艳，等.临床三种常规粪便隐血实验的方法学评估[J].海南医学，2015，27（7）：998-1001.
[12]	任志龙，张璐，刘杰，等.转铁蛋白和尿微量蛋白应用于慢性肾小球肾炎早期诊断的临床应用价值[J].河北医学，2016，22（12）：1987-1989.
[13]	邬振国，董蕾，陈永永，等.急诊内镜下止血联合生长抑素治疗上消化道出血的疗效分析[J].现代生物医学进展，2017，17（22）：4289-4291.
[14]	何治军，邓天伟，王孟仙，等.胶囊内镜对不同年龄人群不明消化道出血的诊断价值[J].中国医药导刊，2016，18（6）：576-578.
[15]	侯德红，李红新，屠文娟，等.粪便乳铁蛋白含量检测在极低出生体质量儿坏死性小肠结肠炎诊断中的意义[J].山东医药，2015，52（36）：73-74.
[16]	Farag A，Barkun AN，Martel M.The utility of fecal occult blood testing for clinical indications of suspected gastrointestinal blood loss outside a setting of colorectal cancer screening：a systematic review[J].Gastroenterology，216，150（4）：S841-S842.