Abstract：Objective To explore the effect of Butylphthalide on plasma lysophosphatidic acid(LPA)level for acute watershed infarction(CWI)and its short-term treatment efficacy.Methods From January 2015 to December 2016,106 patients with CWI were selected as the subject,and devided into the routine treatment group and Butylphthalide group by random number table method,with 53 cases in each group.A total of 50 healthy subjects were selected as the control group.The routine treatment group was treated with conventional antiplatelet therapy.The Butylphthalide group was treated with the same routine procedure,within 48 h after the onset of the disease,the patients were given Butylphthalide injection 100 ml by intravenous drip times a day after operation for 14 d.Plasma lysophosphatidic acid(LPA)level was measured before and after treatment at 7 and 14 d,and the NIHSS scores were compared.Results The plasma LPA level in the routine treatment group and Butylphthalide group were significantly higher than that in control group (P＜0.01).The plasma LPA level in the Butylphthalide group was significantly higher than that in the routine treatment group at 7 d after treatment(P＜0.05).There was no significant difference in plasma LPA level among the three groups at 14 d after treatment(P＞0.05).The NIHSS scores of the butylphthalide group and routine treatment group at 14 d after treatment were higher than before(P＜0.01),and the NIHSS scores of the Butylphthalide group was significantly higher than that in the routine treatment group (P＜0.05).The effective rate and obvious effective rate at 14 d after treatment in Butylphthalide group was higher than those in control group,the differences were statistically significant(P＜0.05).Conclusion The level of plasma LPA in the early stage of acute CWI in patients improves,suggesting that the platelet is activated in vivo.The application of Butylphthalide on the basis of routine therapy can decrease the level of plasma lysophosphatidic acid and reduce the neurologic impairment.
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