PSA及相关参数对PSA＜4.0 ng/ml前列腺癌的诊断价值

摘要
图/表
参考文献(15)
相关文章 (6)

全文: PDF (0 KB) HTML (33 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨前列腺特异性抗原（PSA）及相关参数对PSA＜4.0 ng/ml前列腺癌的诊断价值。方法回顾性分析2006年1～12月广州医科大学第六附属医院和广东医科大学附属中山医院收治的PSA位于PSA＜4.0 ng/ml行前列腺穿刺活检病例320例，根据穿刺活检病理结果将其分为前列腺癌（PCa）组53例和前列腺增生（BPH）组267例，收集患者的血清总前列腺特异抗原（tPSA）、游离前列腺特异抗原（fPSA）、f/tPSA及病理资料，按照f/tPSA比值分成 5 个区间 0.01～0.08、0.09～0.16、0.17～0.24、0.25～0.32、0.33～0.40，比较区间 PCa 检出率。结果两组患者的 t-PSA、f-PSA值比较，差异无统计学意义（P＞0.05）；PCa组患者的f/t PSA值低于BPH组，差异有统计学意义（P＜0.05）。两组患者在 f/t PSA 0.09～0.16、0.17～0.24、0.25～0.32 的 PCa检出率比较，差异有统计学意义（P＜0.05），而两组患者在f/t PSA 0.01～0.08、0.33～0.40的PCa检出率比较，差异无统计学意义（P＞0.05）。结论PSA及PSA相关指标对PSA＜4.0 ng/ml前列腺癌患者具有较好的诊断价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	黄顺坛
	唐顺利
	孙刚

关键词 ：前列腺特异性抗原, 游离前列腺特异抗原与总前列腺特异抗原比值, 前列腺癌

Abstract：Objective To investigate the diagnostic value of prostate specific antigen (PSA)and its related parameters for prostate cancer with PSA＜4.0 ng/ml.Methods A total of 320 cases of prostate biopsy with PSA＜4.0 ng/ml admitted to the 6th affiliated hospital of Guangzhou medical university and Zhongshan hospital of Guangdong medical university from January to December 2016 were retrospectively analyzed.According to the pathological results of the biopsy,they were divided into 53 cases of prostate cancer(PCA)and 267 cases of benign prostatic hyperplasia (BPH).The total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),f/t PSA and pathological data were collected and divided into 5 intervals of 0.01-0.08,0.09-0.16 and 0.17 according to the f/t PSA ratio.Results There was no significant difference between the two groups in tPSA and fPSA values (P＞0.05).The f/t PSA value in PCA group was lower than that in BPH group,the difference was statistically significant(P＜0.05).The PCA detection rates of the two groups of patients in f/t PSA 0.09-0.16,0.17-0.24,0.25-0.32 were statistically significant(P＜0.05),while the PCA detection rates of the two groups of patients in f/t PSA 0.01-0.08,0.33-0.40 were not statistically significant(P＞0.05).Conclusion PSA and PSA-related parameters have a good diagnostic value for the patients with prostate cancer with PSA＜4.0 ng/ml.

Key words： Prostate specific antigen Ratio of free prostate-specific antigen to total prostate-specific antigen Prostate cancer

引用本文:

黄顺坛;唐顺利;孙刚. PSA及相关参数对PSA＜4.0 ng/ml前列腺癌的诊断价值[J]. 中国当代医药, 2018, 25(19): 77-79.
HUANG Shun-tan;TANG Shun-li;SUN Gang. Diagnostic value of PSA and related parameters for prostate cancer with PSA＜4.0 ng/ml. 中国当代医药, 2018, 25(19): 77-79.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I19/77

[1]	Siegel RL，Miller KD，Jemal A.Cancer statistics 2016[J].CA Cancer J Clin，2012，66（1）：7-30.
[2]	李雨升，董胜国，马超，等.F-PSA/T-PSA对T-PSA＜4.0 ng/ml前列腺癌的早期诊断价值[J].山东医药，2015，48（30）：17-18.
[3]	Sokoloff MH，Yang XJ，Fumo M，et al.Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of＜4.0 ng/mL[J].BJU Int，2004,93（4）：499-502.
[4]	党瑞锋，徐勇，张志宏，等.f/t PSA与PSAD对tPSA灰区前列腺癌诊断价值的 Meta 分析[J].天津医药，2015，40（3）：273-276.
[5]	Chen CS，Wang SS，Li JR，et al.PSA density as a better predictor of prostate cancer than percent-free PSA in a repeat biopsy[J].J Chin Med Assoc.2011,74（12）：552-555.
[6]	翟元憬，陈卫民，文丽生，等.FPSA/TPSA、PSATZ、（F/T）/PSAD对PSA灰值区前列腺癌的诊断价值[J].南昌大学学报（医学版），2016，52（7）：25-28.
[7]	Whiting PF，Rutjes AW，Westwood ME，et al.QUADAS-2：a revised tool for the quality assessment of diagnostic accuracy studies[J].Ann Intern Med，2011，155（8）：529-536.
[8]	孙颖浩.前列腺癌诊治进展[J].上海医学，2011，34（7）：487-488.
[9]	Ferreira MD，Koff WJ.Assessment of serum level of prostatespecific antigen adjusted for the transition zone volume in early detection of prostate cancer[J].Int Braz J Urol，2005 Mar-Apr；31（2）：137-145.
[10]	Ozen H，Aygün C，Ergen A，et al.Combined use of prostatespecific antigen derivatives decreases the number of unnecessarybiopsies to detect prostate cancer[J].Am J Clin Oncol，2001，24 （6）：610-613.
[11]	周刚，彭境罗，刘幸生，等.f/t PSA与PSAD对tPSA灰区且直肠指检阴性前列腺癌诊断价值的Meta分析[J].循证医学，2015，15（1）：48-53.
[13]	陈世范，战伟，李剑，等.血清PSA＜4.0 ng/ml的人群中前列腺癌集团筛查的病理学特征[J].中国男科学杂志，2015，22（11）：9-12.
[14]	马明辉，黄庆波，高宇，等.f/tPSA、PSAD、（f/t）/PSAD 在PSA4～20 ng/ml区间对前列腺癌的诊断预测价值[J].微创泌尿外科杂志，2016，4（6）：366-371.
[12]	Kandirali E，Boran C，Serin E，et al.Association of extent and aggressiveness of inflammation with serum PSA levels and PSAdensity in asymptomatic patients[J].Urology，2017，70（4）：743-747.
[15]	Zheng XY，Xie LP，Wang YY，et al.The use of prostate specific antigen （PSA）density in detecting prostate cancer in Chinese men with PSA levels of 4-10 ng/mL[J].J Cancer Res Clin Oncol，2014，134（11）：1207-1210.