Abstract：ObjectiveTo observe the effect of Enalapril combined with calcium carbonate vitamine D3on bonemineral density(BMD)of the elderly patientswith essential hypertension and osteoporosis.MethodsFrom May 2014 to December 2015,a total of 63 elderly patients with essential hypertension and osteoporosis in our hospital were selected as study object and randomly and double-blindly divided into group A(n=32)treated by Enalaprilwith calcium carbonate vitamine D3and group B (n=31)without Enalapril.The two groupswere observed for one year,the levels of 25-OH-vitamin D,serum calcium(Ca2+),serum phosphorus(P),alkaline phosphatase(ALP),parathyroid hormone(PTH),osteocalcin weremeasured before and 3,6,9,12 months after treatment.Bonemineral density (BMD)of lumbar vertebrae and neck weremeasured before and after treatment.ResultsThere was no significant difference in baseline values of serum parameters between two groups(P＞0.05).The total serum 25-OH-vitamin D levels in two groupswere increased 12months after treatment,and which 9 and 12months after treatmentwas significantly higher than the baseline values,however,the levels of 25-OH-vitamin D in two groupswere lower than normal value(30 ng/ml),there was no significnt statistical difference in the levels of 25-OH-vitamin D between two groups(P＞0.05).12months after treatment,serum Ca2+levels of two groups were elevated and within the normal range,no hypercalcemia occurred;serum Ca2+levels of two groups 6,9 and 12 months after treatment compared to the baseline valueswere significantly increased(P＜0.05);there was no statistically significant difference in serum Ca2+levels oftwo groups (P＞0.05).Osteocalcin,PTH,ALP,P compared with baseline values did not change significantly,there was no significant difference between two groups(P＞0.05).BMD(L1-4)value after treatment for one year in group A was significantly higher than that before treatment(P＜0.01);BMD value after treatment for one year in B group compared with before treatment had no obvious change (P＞0.05);after treatment for one year,BMD (L1-4)between two groupswere compared,and the difference was statistically significant(P＜0.05).BMD (neck)values after treatment for one year in two groupswere no higher than before,and there was no statistical difference in BMD(neck)between two groups(P＞0.05).ConclusionBMD value was obviously increased in the elderly patientwith essential hypertension and osteoporosiswho have taken Enalapril and calcium carbonate vitamine D3after treatment for one year.
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