Clinical study of perioperative Amiodarone for preventing atrial fibrillation after pulmonary resection
LIU Xiao-xiong1 XIONG Han-peng1▲ LI Hui2
1.Department of Thoracic Surgery，the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine，Nanchang 330006，China；
2.Department of Anesthesiology，Hospital of Traditional Chinese Medicine of Xinyu City in Jiangxi Province，Xinyu 338000，China
Abstract：Objective To evaluate efficacy and safety of Amiodarone for preventing atrial fibrillation after pulmonary resection. Methods 130 cases of accepting lobectomy or pneumonectomy in the hospital from April 2014 to June 2015 were randomly divided into Amiodarone group （prophylactic use of Amiodarone，n=65）and control group （n=65），incidence of atrial fibrillation during hospitalization in need of treatment and atrial fibrillationmore than 30 s，stay in intensive care unit and total length of hospital stay between two groupswere compared.Results The incidence of atrial fibrillation in the Amiodarone group was 13.8%，significantly lower than 32.3%in the control group（P＜0.05），incidence of atrial fibrillationmore than 30 s in the Amiodarone group was 13.8%，lower than 33.8%in the control group （P＜0.01）；in the Amiodarone group，stay in intensive care unit and the total length of hospital stay was significantly shorter than that in the control group respectively，the difference was statistically significant（P＜0.05）；incidence of postoperative adverse eventswas not statistically significant（P＞0.05）.Conclusion Prophylactic use of Amiodarone can significantly reduce incidence of atrial fibrillation after pulmonary resectio，and significantly reduce residence time in intensive care unit.
Park BJ，Zhang H，Rusch VW，et al.Video-assisted thoracic surgery dose not reduce the incidence of postoperative atrial fibrillation after pulmonary lobectomy［J］.JThorac Cardiovasc Surg，2007，133（3）：775-779.
京公网安备 11010502046607号