Abstract：Objective To investigate the adherence of blood drug concentration monitoring in children patients so as to make an evaluation of the therapeutic window rate and influence of levetiracetamon renal functions and provide a basis for clinically safer，effective and rational use of levetiracetam.Methods The clinical data of children patients who were diagnosed by department of out-patient or the ward room in our hospital as epilepsy from January 2014 to January 2016 and accepted the levetiracetam blood drug concentration monitoring were retrospectively analyzed.Results Both differentmonitoring arrays and different age groups showed statistically significant differences in the therapeutic window rate and blood drug concentration（P＜0.05）；statistically significant difference was seen in the creatinine abnormal rate of different frequency ofmonitoring（P＜0.05）.Conclusion Levetiracetam blood drug concentration varies greatly among different individuals.In consideration of the fact，it is of great necessity to improve the adherence of blood drug concentration monitoring for children patients，ensure regularmonitoring of blood drug concentration and individualized administration.As a consequence，reduced adverse reactions and improved therapeutic effectwill be realized.
包丹丹 ；张桢. 824例（1495例次）左乙拉西坦血药浓度监测结果回顾性分析[J]. 中国当代医药, 2016, 23(23): 123-125.
BAO Dan-dan ；ZHANG Zhen. Retrospective analysis of the monitoring results of levetiracetam blood drug concentration in 824 Cases（1495 case-times）. 中国当代医药, 2016, 23(23): 123-125.
Tian N，Shaw EC，Zack M，et al.Cause-specific mortality among children and young adultswith epilepsy：results from the U.S.National Child Death Review Case Reporting System［J］.Epilepsy Behav，2015，45（4）：31-34.
［4］
Hirose G.An overview of epilepsy：its history，classification，pathophysiology and management［J］.Brain Nerve，2013，65 （5）：509-520.
京公网安备 11010502046607号