Effect and influence factor analysis of intensity modulated radiation theraPy on short-term life quality of Patients with middle and advanced esoPhageal cancer
MO Kai-lan PENG Miao CHEN Xiao-lan WANG Xi-cheng DING Ying
Department of Onco1ogy，the First Affi1iated Hospita1 of Guangdong Pharmaceutica1 University，Guangzhou 510080，China
Abstract：Objective To discuss the effect and ana1yze the inf1uence factors of intensity modu1ated radiation therapy on short-term 1ife qua1ity of patients with midd1e and advanced esophagea1 cancer.Methods 60 patients with esophagea1 cancer treated in our department from June 2012 to May 2015 were se1ected and random1y divided into study group and contro1 group，each with 30 cases.Patients in the study group were given intensity modu1ated radiation therapy，and patients in the contro1 group were given conventiona1 radiotherapy.C1inica1 symptoms and QOL scores of patients were recorded and compared before treatment，at 1 day and 3 months after therapy.Results There were no significant differences in somatic function，ro1e function，emotiona1 function，cognitive function，socia1 function，and genera1 hea1th between two groups at 1 day before and 1 day after treatment（P＞0.05）.At three months after radiotherapy，emotiona1 function was significant1y higher in the study group than that in the contro1 group（P＜0.05），but there were no significant differences in somatic function，ro1e function，cognitive function，socia1 function，and genera1 hea1th between two groups（P＞0.05）.There were no significant differences in scores of asthma，nausea，vomiting，pain，insomnia，constipation，diarrhea，and fatigue（P＞0.05），whi1e the scores of financia1 difficu1ty and appetite 1oss were significant1y 1ower in the study group than those in the contro1 group （P＜0.05）.There were no significant differences in those symptoms between two groups at 3 months after radiotherapy（P＞0.05）.Conclusion Intensity modu1ated radiation therapy has comparab1e efficacy with conventiona1 radiation therapy，which can re1ieve symptoms of patients after 3 months，and it can significant1y improve the emotiona1 function of patients，with 1ower appetite 1oss，indicating that this method is more suitab1e for patients with esophagea1 cancer and is worthy to be promoted.
莫凯岚;彭苗;陈晓兰;王希成;丁颖. 调强放疗对中晚期食管癌患者短期生活质量的影响及其影响因素分析[J]. 中国当代医药, 2016, 23(14): 47-49转53.
MO Kai-lan;PENG Miao;CHEN Xiao-lan;WANG Xi-cheng;DING Ying. Effect and influence factor analysis of intensity modulated radiation theraPy on short-term life quality of Patients with middle and advanced esoPhageal cancer. 中国当代医药, 2016, 23(14): 47-49转53.
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